Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance
Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance
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CD147和Lewis y抗原在卵巢癌中的表达及其与耐药的关系
DOI：
10.1007/s12032-014-0920-9
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发表时间：
2014-05-01
期刊：
影响因子：
3.4
通讯作者：
Lin, Bei
中科院分区：
文献类型：
--
作者：
Gao, Jian;Hu, Zhenhua;Lin, Bei
本研究旨在探讨CD 147和刘易斯y抗原在卵巢上皮性癌组织中的表达与化疗耐药的关系及其临床意义，并分析两者的相关性。92例卵巢癌患者分为化疗耐药组（34例）和药物敏感组（58例）。免疫组化法检测CD 147、刘易斯y抗原与化疗耐药的关系。采用多因素Logistic回归分析卵巢癌化疗耐药与危险因素的关系。采用考克斯模型分析危险因素与预后的关系。耐药组CD 147和刘易斯y抗原阳性率分别为94.12%和91.67%，明显高于敏感组的77.59%和60.34%。多因素分析显示，CD 147和刘易斯y抗原表达及卵巢癌病理分期均为卵巢癌耐药的独立危险因素。CD 147和刘易斯y抗原在耐药组表达增高，两者呈正相关。CD 147和刘易斯y抗原在卵巢上皮中的表达在耐药组明显增高，且两者在卵巢上皮中的表达呈正相关。CD 147、刘易斯y抗原表达及卵巢癌病理分期均为卵巢癌耐药及预后的独立危险因素。
The purpose of this study was to investigate the relationship between the expression of CD147 and Lewis y antigen in epithelial ovarian carcinoma tissues and resistance to chemotherapeutic drugs, and its underlying clinical significance, and to analyze the correlation between the expression of CD147 and Lewis y antigen. Ninety-two ovarian cancer patients were divided into a chemotherapeutic-drug-resistant group (34 patients) and a drug-sensitive group (58 patients). Immunohistochemical assays were used to measure CD147, and Lewis y antigen to investigate their correlation with chemotherapy resistance. Multivariate logistic regression was used to analyze the relationships between risk factors and resistance to chemotherapy in ovarian cancer. Cox’s model was used to analyze the relationships between risk factors and prognosis. The proportion of tissues expressing CD147 and Lewis y antigen in the drug-resistant group were 94.12 and 91.67 %, respectively, which were significantly higher than those in the sensitive group (77.59 and 60.34 %, respectively). The multivariate analysis indicated that the expression of CD147 and Lewis y antigen and the pathological stage of the ovarian cancer were all independent risk factors for drug resistance. Expression of CD147 and Lewis y antigen was high in the resistant group, and they correlated positively with each other. The expression of CD147 and Lewis y antigen was significantly higher in the drug-resistant group and their expression correlated positively in the ovarian epithelium. The expression of CD147 and Lewis y antigen and the pathological stage of ovarian cancer were all independent risk factors for drug resistance and prognosis in ovarian cancer.