Antibody to the M(r) 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese.
Antibody to the M(r) 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese.
复制标题
在日本的非胰岛素依赖型糖尿病中检测到谷氨酸脱羧酶 M(r) 65,000 亚型的抗体。
DOI：
10.1006/jaut.1996.0013
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发表时间：
1996
影响因子：
12.8
通讯作者：
Saruta,T
中科院分区：
文献类型：
--
作者：
Kasuga,A;Maruyama,T;Ozawa,Y;Takei,I;Falorni,A;Lernmark,A;Saruta,T
最近有报道称，抗谷氨酸脱羧酶（GADAb）抗体对非胰岛素依赖型糖尿病（NIDDM）患者的胰岛素依赖具有很高的阳性预测价值。我们研究了289例发病时被分类为NIDDM的患者。GAD65Ab阳性的患者发病年龄较轻，身体质量指数（BMI）较低，血清c肽浓度较低，并且更常使用胰岛素治疗。在73例胰岛素治疗患者中，c肽水平较低的患者（n=30， c肽≤0.9ng/ml） GAD65Ab的频率（46.7%）高于c肽水平正常的患者（n=53， c肽>0.9;7.5%，P<0.0001）。其余206例未接受胰岛素治疗的患者分为48例短期患者（诊断后不到5年）和158例长期患者。病程短的患者GAD65Ab频率（10.4%）显著高于病程长的患者（3.2%，P<0.05）。在短期患者中，gad65阳性和阴性患者的c肽水平无显著差异（分别为2.175和2.226ng/ml）。综上所述，GAD65Ab作为胰岛素缺乏的标志物，可能在血清c肽浓度下降前预测非胰岛素依赖型日本糖尿病患者是否发生胰岛素依赖。
It was recently reported that antibodies against glutamic acid decarboxylase (GADAb) have a high positive predictive value for insulin-dependency in non-insulin-dependent diabetic (NIDDM) patients. We studied 289 patients classified at onset as having NIDDM. Patients positive for GAD65Ab had a disease onset at a younger age, lower body mass index (BMI) and lower serum C-peptide concentration, and were more often treated with insulin. Among 73 insulin-treated patients, patients with lower C-peptide level (n=30, C-peptide≤0.9ng/ml) showed a higher frequency of GAD65Ab (46.7%) than patients with normal C-peptide (n=53, C-peptide>0.9; 7.5%,P<0.0001). The 206 remaining non-insulin-treated patients were divided into 48 short-duration (less than 5 years from diagnosis) and 158 long-duration patients. Frequency of GAD65Ab in short-duration patients (10.4%) was significantly higher than that in long-duration patients (3.2%,P<0.05). Among short-duration patients, there was no significant difference in C-peptide levels between GAD65-positive and negative patients (2.175 and 2.226ng/ml). In conclusion, GAD65Ab, a marker of insulin deficiency, may predict the development of insulin dependency in non-insulin-dependent Japanese diabetic patients before serum C-peptide concentration decreases.
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影响因子：
15.9
作者：
CHABNER, BA;JOHNS, DG;EVANS, WH
通讯作者：
EVANS, WH
持续输注大剂量阿糖胞苷治疗难治性儿童白血病。
DOI：
10.1200/jco.1984.2.10.1092
发表时间：
1984
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Ochs,J;Sinkule,JA;Danks,MK;Look,AT;Bowman,WP;Rivera,G
通讯作者：
Rivera,G
来自未经治疗的急性白血病患者的骨髓细胞和外周血细胞在软琼脂中形成白血病细胞集落。
影响因子：
2.6
作者：
Dicke,KA;Tindle,SE;Davis,FM;Jagannath,S;Tucker,S;Lilien,M;vanLeeuwen,P;Verma,DS;Vellekoop,L
通讯作者：
Vellekoop,L
ANLL 患者的母细胞对 ara-C 的代谢。
影响因子：
20.3
作者：
Ross,DD;Thompson,BW;Joneckis,CC;Akman,SA;Schiffer,CA
通讯作者：
Schiffer,CA
影响因子：
11.2
作者：
J. Liliemark;W. Plunkett
通讯作者：
J. Liliemark;W. Plunkett