Preliminary Evidence of the Short Allele of the Serotonin Transporter Gene Predicting Poor Response to Cognitive Behavior Therapy in Posttraumatic Stress Disorder
Preliminary Evidence of the Short Allele of the Serotonin Transporter Gene Predicting Poor Response to Cognitive Behavior Therapy in Posttraumatic Stress Disorder
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DOI：
10.1016/j.biopsych.2010.03.016
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发表时间：
2010-06-15
影响因子：
10.6
通讯作者：
Schofield, Peter R.
中科院分区：
文献类型：
--
作者：
Bryant, Richard A.;Felmingham, Kim L.;Schofield, Peter R.
目的：本研究旨在评估5 -羟色胺转运基因启动子的低表达等位基因在多大程度上预测创伤后应激障碍（PTSD）患者对认知行为治疗的不良反应。方法：45例PTSD患者接受为期8周的暴露认知行为治疗，提供口腔拭子或唾液样本提取基因组DNA，并根据5-HTTLPR的4种等位基因形式(S(A)、S(G)、L（A)、L(G)）对个体进行分类。我们确定5-HTTLPR基因型是否预测治疗后（n = 45）和6个月后（n = 42） PTSD严重程度的变化。结果：在控制治疗前PTSD严重程度和治疗次数后，5-HTTLPR低表达基因型组（S或L，等位基因携带者）在治疗后6个月的PTSD表现较其他患者严重。结论：本研究提示认知行为治疗后的治疗结果与遗传有关，并暗示应激障碍暴露治疗中血清素能系统的反应。
Objective: This study was intended to assess the extent to which the low-expression alleles of the serotonin transporter gene promoter predict poor response to cognitive behavior therapy in patients with posttraumatic stress disorder (PTSD).Method: Forty-five patients with PTSD underwent an 8-week exposure-based cognitive behavior therapy program and provided mouth swabs or saliva samples to extract genomic DNA and classify individuals according to four allelic forms (S(A), S(G), L(A), L(G)) of the 5-HTT-linked polymorphic region (5-HTTLPR). We determined whether the 5-HTTLPR genotype predicted change in PTSD severity following treatment (n = 45) and 6 months later (n = 42).Results: After controlling for pretreatment PTSD severity and number of treatment sessions, the 5-HTTLPR low-expression genotype group (S or L, allele carriers) displayed more severe PTSD 6 months following treatment relative to other patients.Conclusions: This study suggests a genetic contribution to treatment outcome following cognitive behavior therapy and implicates the serotonergic system in response to exposure-based treatments in PTSD.