THE FINE STRUCTURE OF THE RETINA STUDIED WITH THE ELECTRON MICROSCOPE .4. MORPHOGENESIS OF OUTER SEGMENTS OF RETINAL RODS
THE FINE STRUCTURE OF THE RETINA STUDIED WITH THE ELECTRON MICROSCOPE .4. MORPHOGENESIS OF OUTER SEGMENTS OF RETINAL RODS
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DOI：
10.1083/jcb.6.2.225
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发表时间：
1959-01-01
期刊：
影响因子：
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通讯作者：
YAMADA, E
中科院分区：
文献类型：
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作者：
TOKUYASU, K;YAMADA, E
本文主要研究了小猫在睁眼前视网膜杆外段的形态发生，并推测了各形态发生阶段的可能顺序。由于视网膜视杆细胞的发育是不同步的，所以这些推论是基于对许多单个和连续切片的观察。一个中心粒延伸约0.5 [mu]长的纤毛小管，在生长的原始纤毛。超过这个长度，每个睫状小管变成一排小泡（本文称为“睫状泡”），这些小泡渗透到纤毛的远端区域。在纤毛囊泡与纤毛远端区域的质膜建立接触的地方，观察到质膜或多或少的深内折。在远端区域可以看到成排的管状囊状结构。这些膜状结构中的一些与内折的底部是连续的。在随后的阶段，内折叠消失，纤毛囊泡失去与远端质膜的接触。尽管如此，管状结构的形成在原始外段的远端区域中继续。管状结构似乎通过侧向扩大转变为原始杆囊。在随后的时间，大概，这些原始杆囊变平，并重新排列成垂直于外节长轴的位置。通过连续切片的方法，对连接纤毛基体的详细结构进行了研究。
The morphogenesis of the outer segments of retinal rods was studied mainly in the kitten before the opening of the eye, and the probable sequence of the morphogenetic stages is deduced. Since the development of retinal rods is not synchronous, the deductions were based on observations of many single and serial sections. One centriole extends ciliary tubules of about 0.5 [mu] long, in the growing primitive cilium. Beyond this length, each ciliary tubule becomes a row of small vesicles (called "ciliary vesicles" in this paper), which penetrate into the distal region of the cilium. Where the ciliary vesicles establish contact with the plasma membrane of the distal region of the cilium, more or less deep infoldings of the plasma membrane are observed. In the distal region can be seen rows of tubular of vesicular structures. A few of these membranous structures are continuous with the bottoms of the infoldings. At the following stage, the infoldings disappear and the ciliary vesicles lose contact with the distal plasma membrane. Nonetheless, the formation of the tubular structures continues in the distal region of the primitive outer segment. The tubular structures appear to be transformed into the primitive rod sacs by sidewise enlargement. At a subsequent time, presumably, these primitive rod sacs flatten and are rearranged into a position perpendicular to the long axis of the outer segment. The detailed structure of the basal body of the connecting cilium was also studied by means of serial sections.