Interleukin 6 is associated with cachexia in patients with prostate cancer
Interleukin 6 is associated with cachexia in patients with prostate cancer
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DOI：
10.1016/j.urology.2006.09.039
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发表时间：
2007-01-01
期刊：
影响因子：
2.1
通讯作者：
Murai, Masaru
中科院分区：
文献类型：
--
作者：
Kuroda, Kenji;Nakashima, Jun;Murai, Masaru
目的探讨前列腺癌患者血清白细胞介素(IL)-6与恶病质的关系。方法测定164例前列腺癌患者血清IL-6、总蛋白、白蛋白、总胆固醇和血红蛋白浓度。测定体重指数和运动状态。结果血清IL-6≥7 pg/mL的患者血清总蛋白、白蛋白、胆固醇水平、血红蛋白水平、体重指数均显著低于低于7 pg/mL的患者（P < 0.05）。血清白蛋白水平小于3.5 g/dL、血清总蛋白水平小于7.0 g/dL、血清总胆固醇水平小于180 mg/dL、血红蛋白水平小于11.0 g/dL、体重指数小于21 kg/m(2)的患者血清IL-6水平显著高于相应组（P < 0.05）。血清IL-6的升高与生产性能有显著相关性（P < 0.05）。血清IL-6水平较高患者的死亡率显著高于未治疗、缓解期和复发期血清IL-6水平较低患者（均P < 0.05）。结论IL-6可能是前列腺癌患者恶病质复杂综合征发生的因素之一（均P < 0.05）。(c) 2007爱思唯尔公司
OBJECTIVES To evaluate the relationship between serum interleukin (IL)-6 and cachexia in patients with prostate cancer.METHODS Serum levels of IL-6, total protein, albumin, total cholesterol, and hemoglobin concentration were determined in 164 blood samples from patients with prostate cancer. The body mass index and performance status were also determined.RESULTS The serum total protein, albumin, and cholesterol levels, hemoglobin levels, and body mass index of the patients whose serum IL-6 level was 7 pg/mL or greater were significantly lower (P < 0.05) than the corresponding values in patients with a serum IL-6 level of less than 7 pg/mL. The serum IL-6 level of patients with a serum albumin level of less than 3.5 g/dL, serum total protein level of less than 7.0 g/dL, serum total cholesterol level of less than 180 mg/dL, hemoglobin level of less than 11.0 g/dL, and body mass index of less than 21 kg/m(2) were significantly greater (P < 0.05) than the values in their respective counterparts. A significant correlation was found between the elevation of serum IL-6 and performance status (P < 0.05). The mortality rate of patients with greater serum IL-6 levels was significantly greater than that of those with lower serum IL-6 levels in patients with untreated disease, patients in remission, and patients with relapse (all P < 0.05).CONCLUSIONS These findings suggest that IL-6 may be one of the factors contributing to the complex syndrome of cachexia inpatients with prostate cancer (all P < 0.05). (c) 2007 Elsevier Inc.