Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamsters.
Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamsters.
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DOI：
10.1038/s41423-022-00923-9
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发表时间：
2022-12
影响因子：
24.1
通讯作者：
Xia, Ningshao
中科院分区：
文献类型：
--
作者：
Yuan, Lunzhi;Zhu, Huachen;Chen, Peiwen;Zhou, Ming;Ma, Jian;Liu, Xuan;Wu, Kun;Chen, Rirong;Liu, Qiwei;Yu, Huan;Li, Lifeng;Wang, Jia;Zhang, Yali;Ge, Shengxiang;Yuan, Quan;Tang, Qiyi;Cheng, Tong;Guan, Yi;Xia, Ningshao
新的主要流行的SARS-CoV-2变体Omicron可以强大地逃避当前的疫苗和中和抗体。虽然Omicron的复制和疾病表现比一些早期的变体更温和，但其在不同年龄组中的致病性尚未得到很好的阐明。在这里，我们报告了SARS-CoV-2 Omicron BA.1亚系在幼年和老年仓鼠中引起感染和肺发病率升高，这些仓鼠的体重减轻、呼吸道病毒负荷和肺损伤比成年仓鼠更多。幼年仓鼠对Omicron BA.1感染的干扰素应答降低，而老年仓鼠表现出过度的促炎细胞因子表达、延迟的病毒清除和加重的肺损伤。早期吸入IFN-α2b治疗可抑制幼年和成年仓鼠Omicron BA.1感染和肺部发病。总体而言，数据表明先天免疫应答的不同模式影响不同年龄组中Omicron BA.1感染的疾病结局。
The new predominant circulating SARS-CoV-2 variant, Omicron, can robustly escape current vaccines and neutralizing antibodies. Although Omicron has been reported to have milder replication and disease manifestations than some earlier variants, its pathogenicity in different age groups has not been well elucidated. Here, we report that the SARS-CoV-2 Omicron BA.1 sublineage causes elevated infection and lung pathogenesis in juvenile and aged hamsters, with more body weight loss, respiratory tract viral burden, and lung injury in these hamsters than in adult hamsters. Juvenile hamsters show a reduced interferon response against Omicron BA.1 infection, whereas aged hamsters show excessive proinflammatory cytokine expression, delayed viral clearance, and aggravated lung injury. Early inhaled IFN-α2b treatment suppresses Omicron BA.1 infection and lung pathogenesis in juvenile and adult hamsters. Overall, the data suggest that the diverse patterns of the innate immune response affect the disease outcomes of Omicron BA.1 infection in different age groups.
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影响因子：
64.8
作者：
Muñoz-Fontela C;Dowling WE;Funnell SGP;Gsell PS;Riveros-Balta AX;Albrecht RA;Andersen H;Baric RS;Carroll MW;Cavaleri M;Qin C;Crozier I;Dallmeier K;de Waal L;de Wit E;Delang L;Dohm E;Duprex WP;Falzarano D;Finch CL;Frieman MB;Graham BS;Gralinski LE;Guilfoyle K;Haagmans BL;Hamilton GA;Hartman AL;Herfst S;Kaptein SJF;Klimstra WB;Knezevic I;Krause PR;Kuhn JH;Le Grand R;Lewis MG;Liu WC;Maisonnasse P;McElroy AK;Munster V;Oreshkova N;Rasmussen AL;Rocha-Pereira J;Rockx B;Rodríguez E;Rogers TF;Salguero FJ;Schotsaert M;Stittelaar KJ;Thibaut HJ;Tseng CT;Vergara-Alert J;Beer M;Brasel T;Chan JFW;García-Sastre A;Neyts J;Perlman S;Reed DS;Richt JA;Roy CJ;Segalés J;Vasan SS;Henao-Restrepo AM;Barouch DH
通讯作者：
Barouch DH
影响因子：
64.8
作者：
Domizio JD;Gulen MF;Saidoune F;Thacker VV;Yatim A;Sharma K;Nass T;Guenova E;Schaller M;Conrad C;Goepfert C;de Leval L;Garnier CV;Berezowska S;Dubois A;Gilliet M;Ablasser A
通讯作者：
Ablasser A
影响因子：
82.9
作者：
Gao Y;Cai C;Grifoni A;Müller TR;Niessl J;Olofsson A;Humbert M;Hansson L;Österborg A;Bergman P;Chen P;Olsson A;Sandberg JK;Weiskopf D;Price DA;Ljunggren HG;Karlsson AC;Sette A;Aleman S;Buggert M
通讯作者：
Buggert M
DOI：
10.2807/1560-7917.es.2021.26.50.2101147
发表时间：
2021-12
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Brandal LT;MacDonald E;Veneti L;Ravlo T;Lange H;Naseer U;Feruglio S;Bragstad K;Hungnes O;Ødeskaug LE;Hagen F;Hanch-Hansen KE;Lind A;Watle SV;Taxt AM;Johansen M;Vold L;Aavitsland P;Nygård K;Madslien EH
通讯作者：
Madslien EH
影响因子：
56.9
作者：
McCallum, Matthew;Czudnochowski, Nadine;Rosen, Laura E.;Zepeda, Samantha K.;Bowen, John E.;Walls, Alexandra C.;Hauser, Kevin;Joshi, Anshu;Stewart, Cameron;Dillen, Josh R.;Powell, Abigail E.;Croll, Tristan, I;Nix, Jay;Virgin, Herbert W.;Corti, Davide;Snell, Gyorgy;Veesler, David
通讯作者：
Veesler, David