Differential chemoprotection of normal and malignant tissues.
Differential chemoprotection of normal and malignant tissues.
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正常和恶性组织的差异化学保护。
DOI：
10.1093/jnci/42.2.331
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
J. Storer
中科院分区：
文献类型：
--
作者：
J. Yuhas;J. Storer
已经测试了辐射防护剂WR-2721（S-2-[3-氨基丙基氨基]乙基硫代磷酸酯）（或其保护小鼠免受X射线诱导的致死性和X射线诱导的皮肤溃疡的能力，以及其保护可移植乳腺肿瘤免受辐射诱导的可移植性抑制的能力）。在X射线照射前15分钟注射WR-2721（500 mg/kg）可使30天内诱导50%致死率（LD 50/30）所需的剂量增加160- 170%，使50%小鼠皮肤溃疡所需的X射线剂量增加140%，但抑制肿瘤可移植性所需的剂量仅增加15%。这种不同的保护活性，即使范围有限，应进一步研究，以评估放射防护剂在放射治疗中的潜在用途。
The radioprotective agent, WR-2721 (S-2-[3-aminopropylamino] ethylphosphorothioate), has been tested (or its ability to protect mice against X-ray-induced lethality and against X-ray-induced skin ulceration, and for its ability to protect a transplantable mammary tumor against radiation-induced inhibition of transplantability. Injection of WR-2721 (500 mg/kg) 15 minutes before X-ray exposures increases the dose required to induce 50% lethality within 30 days (LD50/30) by 160–170%, increases the X-ray dose required to induce skin ulceration in 50% of the mice by 140%, but increases the dose required to inhibit tumor transplantability by only 15%. This differential protective activity, even though limited in scope, should be investigated further to assess the potential usefulness of radioprotective agents in radiotherapy.