Prevention strategies for esophageal cancer: Perspectives of the East vs. West
Prevention strategies for esophageal cancer: Perspectives of the East vs. West
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DOI：
10.1016/j.bpg.2015.09.010
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发表时间：
2015-12-01
影响因子：
3.2
通讯作者：
Wu, Ming-Shiang
中科院分区：
文献类型：
--
作者：
Chung, Chen-Shuan;Lee, Yi-Chia;Wu, Ming-Shiang
食管癌是全球第八大常见癌症。食管腺癌（EAC）和食管鳞状细胞癌（ESCC）分别是西方和东方国家的两种主要表型。由于发生癌变的途径不同，食管癌的危险因素和有效预防措施在EAC和ESCC之间存在差异。EAC的癌变是由胃对食管粘膜的酸暴露引起的，而ESCC的癌变则主要与酒精、香烟、槟榔液和热饮等致癌物的慢性刺激有关。为消除食管癌对全球健康的负担，应采取由一级、二级和三级预防组成的有效策略。在这篇文章中，我们对食管癌的预防策略进行了系统的回顾，特别强调从西方和东方国家的角度来看的差异。(C) 2015 Elsevier Ltd.版权所有。
Esophageal cancer is the eighth most common cancer worldwide. Esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) are the two major phenotypes in Western and Eastern countries, respectively. Because of different pathways in carcinogenesis, the risk factors and effective steps for prevention of esophageal cancer are different between EAC and ESCC. The carcinogenesis of EAC is initiated by the acid exposure of the esophageal mucosa from stomach while that of the ESCC are related to the chronic irritation of carcinogens mainly by the alcohol, cigarette, betel quid, and hot beverage. To eliminate the burden of esophageal cancer on the global health, the effective strategy should be composed of the primary, secondary, and tertiary prevention. In this article, we perform a systematic review of the preventive strategies for esophageal cancer with special emphasis on the differences from the perspectives of Western and Eastern countries. (C) 2015 Elsevier Ltd. All rights reserved.