Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs.
Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs.
复制标题
5-羟色胺1B受体通过门控呼叫和海马输入来调节前额叶功能。
DOI：
10.1016/j.celrep.2016.11.036
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发表时间：
2016-12-13
期刊：
影响因子：
8.8
通讯作者：
Sohal VS
中科院分区：
文献类型：
--
作者：
Kjaerby C;Athilingam J;Robinson SE;Iafrati J;Sohal VS
Both the medial prefrontal cortex (mPFC) and serotonin play key roles in anxiety, however, specific mechanisms through which serotonin might act on the mPFC to modulate anxiety-related behavior remain unknown. Here, we use a combination of optogenetics and synaptic physiology to show that serotonin acts presynaptically via 5-HT1B receptors to selectively suppress inputs from the contralateral mPFC and ventral hippocampus (vHPC), while sparing those from mediodorsal thalamus. To elucidate how these actions could potentially regulate prefrontal circuit function, we infused a 5-HT1B agonist into the mPFC of freely behaving mice. Consistent with previous studies that have optogenetically inhibited vHPC-mPFC projections, activating prefrontal 5-HT1B receptors suppressed theta-frequency (4–12 Hz) mPFC activity, and also reduced avoidance of anxiogenic regions in the elevated plus maze. These findings suggest a potential mechanism, linking specific receptors, synapses, patterns of circuit activity, and behavior, through which serotonin may regulate prefrontal circuit function including anxiety-related behaviors.
