TOPOGRAPHICAL RELATIONSHIPS BETWEEN OLFACTORY RECEPTOR-CELLS AND GLOMERULAR FOCI IN THE RAT OLFACTORY-BULB
TOPOGRAPHICAL RELATIONSHIPS BETWEEN OLFACTORY RECEPTOR-CELLS AND GLOMERULAR FOCI IN THE RAT OLFACTORY-BULB
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DOI：
10.1016/0006-8993(87)91204-2
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发表时间：
1987-10-20
期刊：
影响因子：
2.9
通讯作者：
HOLLEY, A
中科院分区：
文献类型：
--
作者：
ASTIC, L;SAUCIER, D;HOLLEY, A
我们研究了15日龄大鼠不同球表面注射HRP后投射至肾小球病灶的嗅觉受体细胞的分布模式。HRP标记仅与2-4个相邻肾小球重叠，并且沿前后（A-P）轴的最大范围为沿着260 μ m。HRP注射被限制到足以允许标记的个体受体细胞在上皮片层中被辨别。结果表明，神经元终止于一个给定的球表面的一些连续的肾小球分布在大多数区域投影到这个球表面。此外，在这些上皮区域内，标记细胞主要分布在鼻子的额轴和A-P轴上。当在鼻甲骨或鼻隐窝上观察到少数充满HRP的神经元时，它们的分布似乎是按照沿着A-P鼻轴的某种排列来组织的。我们的研究结果表明，第一次的主要特征的区域组织的上皮细胞的投影到一个给定的球表面复制在任何肾小球焦点的球表面，并建议它可能是相同的任何单一的肾小球。这种投射原理支持外周和球之间解剖关系中的大的红细胞的概念。
We have studied the distribution patterns of olfactory receptor cells that project to glomerular foci after HRP injections in the different bulbar surfaces of 15-day-old rats. HRP label overlapped only 2-4 contiguous glomeruli and had a maximal extent of 260 .mu.m along the antero-posterior (A-P) axis. HRP injections were confined enough to allow labeled individual receptor cells to be discerned in the epithelial sheet. Results have shown that neurons ending in a few contiguous glomeruli of a given bulbar surface were distributed in most of the regions projecting to this bulbar surface. Moreover, within these epithelial areas, labeled cells were largely dispersed in both the frontal and the A-P axes of the nose. When few HRP-filled neurons were observed on a turbinate or a recess, their distribution seemed organized according to a certain alignment along the A-P nasal axis. Our findings demonstrate for the first time that the principal features of the regional organization of epithelium projections to a given bulbar surface are reproduced in any glomerular focus of this bulbar surface, and suggest that it could be the same for any single glomerulus. Such a principle of projection supports the concept of a large redundance in the anatomical relationship between periphery and bulb.