Term stillbirth caused by oral Fusobacterium nucleatum.
Term stillbirth caused by oral Fusobacterium nucleatum.
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DOI：
10.1097/aog.0b013e3181cb9955
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发表时间：
2010-02
影响因子：
7.2
通讯作者：
Redline RW
中科院分区：
文献类型：
--
作者：
Han YW;Fardini Y;Chen C;Iacampo KG;Peraino VA;Shamonki JM;Redline RW
宫内感染是公认的不良妊娠结局的原因，但感染源往往无法确定。我们报告一例由核梭杆菌引起的死产，起源于母亲的口腔。一名患有妊娠相关性牙周炎的妇女在足月时经历了上呼吸道感染，几天后死产。从胎盘和婴儿体内分离到核梭杆菌。对母亲不同微生物菌群的检查发现，在她的牙龈下菌斑中发现了相同的克隆，但在牙龈上菌斑、阴道或直肠中没有。在呼吸道感染期间，当免疫系统减弱时，核纤毛虫可能从母亲的口腔转移到子宫。这一案例为妊娠相关牙周炎患者的治疗提供了新的思路。
Intrauterine infection is a recognized cause of adverse pregnancy outcome but the source of infection is often undetermined. We report a case of stillbirth caused by Fusobacterium nucleatum that originated in the mother’s mouth. A woman with pregnancy-associated gingivitis experienced an upper respiratory tract infection at term, followed by stillbirth a few days later. Fusobacterium nucleatum was isolated from the placenta and the infant. Examination of different microbial flora from the mother identified the same clone in her subgingival plaque, but not in the supragingival plaque, vagina, or rectum. F. nucleatum may have translocated from the mother’s mouth to the uterus when the immune system was weakened during the respiratory infection. This case sheds light on patient management for those with pregnancy-associated gingivitis.