Risk Factors for Pulmonary Artery Hypertension in Preterm Infants with Moderate or Severe Bronchopulmonary Dysplasia
Risk Factors for Pulmonary Artery Hypertension in Preterm Infants with Moderate or Severe Bronchopulmonary Dysplasia
复制标题
DOI：
10.1159/000327891
复制
发表时间：
2012-01-01
期刊：
影响因子：
2.5
通讯作者：
Choi, Jung-Hwan
中科院分区：
文献类型：
--
作者：
Kim, Do-Hyun;Kim, Han-Suk;Choi, Jung-Hwan
背景：尽管肺动脉高压（PAH）对支气管肺发育不良（BPD）早产儿的潜在重要性，但对PAH的危险因素知之甚少。目的：探讨BPD早产儿多环芳烃的危险因素。方法：除无PAH的轻度BPD婴儿外，将诊断为BPD的婴儿分为PAH组和非PAH组。超声心动图显示右心室压力高于出生后2个月，诊断为PAH。采用Logistic回归分析对中度或重度BPD早产儿PAH的危险因素进行多因素评估。结果：145例BPD患儿中98例分为PAH组（n = 25）和非PAH组（n = 73），其余47例患儿为轻度BPD，无PAH。在研究患者中，PAH组的生存率明显低于非PAH组。与没有PAH的婴儿相比，PAH婴儿有更严重的BPD病例，需要更长时间的氧气治疗、常规或高频通气和住院治疗。5分钟Apgar评分低(
Background: Despite the potential importance of pulmonary artery hypertension (PAH) in preterm infants with bronchopulmonary dysplasia (BPD), little is known about the risk factors for PAH. Objectives: To investigate the risk factors for PAH in preterm infants with BPD. Methods: Infants diagnosed with BPD were assigned to the PAH group or non-PAH group except for infants with mild BPD who had no PAH. PAH was diagnosed on the basis of echocardiograms demonstrating elevated right ventricle pressure beyond the postnatal age of 2 months. Logistic regression analysis was done for the multivariate assessment of the risk factors for PAH in preterm infants with moderate or severe BPD. Results: A total of 98 infants among 145 infants with BPD were divided into a PAH group (n = 25) or non-PAH group (n = 73), while the remaining 47 infants had mild BPD with no PAH. Among the study patients, survival rate of the PAH group was significantly lower than that of the non-PAH group. Infants with PAH had more severe cases of BPD and underwent longer durations of oxygen therapy, conventional or high-frequency ventilation, and hospitalization compared to those without PAH. Low 5-min Apgar scores (