Neurosurgical hand-held optical coherence tomography (OCT) forward-viewing probe
Neurosurgical hand-held optical coherence tomography (OCT) forward-viewing probe
复制标题
神经外科手持式光学相干断层扫描 (OCT) 前视探头
DOI：
10.1117/12.909116
复制
发表时间：
2012
影响因子：
2.7
通讯作者：
V. Yang
中科院分区：
文献类型：
--
作者：
Cuiru Sun;K. Lee;B. Vuong;M. Cusimano;Alexander Brukson;A. Mariampillai;B. Standish;V. Yang
一种原型神经外科手持式光学相干断层扫描（OCT）成像探针已经开发出来，可以在开放手术期间提供微米分辨率的表面下组织横切面图像。这种新的符合人体工程学的手持探针是基于我们小组以前在静电驱动光纤上的工作而设计的。它已被包装成导管探头在熟悉的形状因素临床上接受的卡刀形神经外科非成像多普勒超声探头。利用ZEMAX仿真对光学设计进行优化。对探头的光学性能进行了测试，得到了~ 20um的光斑尺寸，5mm的工作距离和3.5 mm的视场。扫描频率可以通过改变施加的电压来增加或减少。通常选择小于60Hz的扫描频率来保持施加的电压小于2000V。探头的轴向分辨率为~ 15um（在空气中），由OCT系统确定。一种定制触发方法已经开发出来，以提供连续稳定的成像，这对临床应用至关重要。该探头与1310 nm扫描源OCT系统的可行性进行了测试，并展示了图像，以突出这种前视手持式OCT成像探头的实用性。从本研究中获得的知识将为开发新的OCT技术用于脑动脉瘤的血管内治疗和经蝶窦神经内窥镜治疗垂体肿瘤奠定基础。
A prototype neurosurgical hand-held optical coherence tomography (OCT) imaging probe has been developed to provide micron resolution cross-sectional images of subsurface tissue during open surgery. This new ergonomic hand-held probe has been designed based on our group's previous work on electrostatically driven optical fibers. It has been packaged into a catheter probe in the familiar form factor of the clinically accepted Bayonet shaped neurosurgical non-imaging Doppler ultrasound probes. The optical design was optimized using ZEMAX simulation. Optical properties of the probe were tested to yield an ~20 um spot size, 5 mm working distance and a 3.5 mm field of view. The scan frequency can be increased or decreased by changing the applied voltage. Typically a scan frequency of less than 60Hz is chosen to keep the applied voltage to less than 2000V. The axial resolution of the probe was ~15 um (in air) as determined by the OCT system. A custom-triggering methodology has been developed to provide continuous stable imaging, which is crucial for clinical utility. Feasibility of this probe, in combination with a 1310 nm swept source OCT system was tested and images are presented to highlight the usefulness of such a forward viewing handheld OCT imaging probe. Knowledge gained from this research will lay the foundation for developing new OCT technologies for endovascular management of cerebral aneurysms and transsphenoidal neuroendoscopic treatment of pituitary tumors.
影响因子：
3.6
作者：
Yuli Wang;M. Bachman;Guann-Pyng Li;Shuguang Guo;B. Wong;Zhongping Chen
通讯作者：
Yuli Wang;M. Bachman;Guann-Pyng Li;Shuguang Guo;B. Wong;Zhongping Chen
开放膝盖手术期间骨关节炎软骨的高分辨率光学相干断层扫描成像。
影响因子：
4.9
作者：
Li, Xingde;Martin, Scott;Pitris, Costas;Ghanta, Ravi;Stamper, Debra L;Harman, Michelle;Fujimoto, James G;Brezinski, Mark E
通讯作者：
Brezinski, Mark E