TNF-α induction of CD44-mediated leukocyte adhesion by sulfation
TNF-α induction of CD44-mediated leukocyte adhesion by sulfation
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DOI：
10.1126/science.282.5390.941
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发表时间：
1998-10-30
期刊：
影响因子：
56.9
通讯作者：
Johnson, P
中科院分区：
文献类型：
--
作者：
Maiti, A;Maki, G;Johnson, P
细胞粘附的调节对于免疫系统功能很重要。 CD44 是白细胞上存在的一种严格调节的细胞粘附分子，在炎症免疫反应过程中参与白细胞与内皮细胞的附着。促炎细胞因子肿瘤坏死因子-α（而非干扰素-γ）被发现通过诱导 CD44 硫酸化，将 CD44 从非活性、非结合形式转化为活性形式。这种翻译后修饰对于 CD44 介导的与细胞外基质成分透明质酸和血管内皮细胞的结合是必需的。因此，硫酸化是调节炎症部位 CD44 介导的白细胞粘附的潜在手段。
Regulation of cell adhesion is important for immune system function. CD44 is a tightly regulated cell adhesion molecule present on Leukocytes and implicated in their attachment to endothelium during an inflammatory immune response. The proinflammatory cytokine tumor necrosis factor-alpha, but not interferon-gamma, was found to convert CD44 from its inactive, nonbinding form to its active form by inducing the sulfation of CD44. This posttranslational modification was required for CD44-mediated binding to the extracellular matrix component hyaluronan and to vascular endothelial cells. Sulfation is thus a potential means of regulating CD44-mediated Leukocyte adhesion at inflammatory sites.