Chagas' disease: selective affinity and cytotoxicity of Trypanosoma cruzi-immune lymphocytes to parasympathetic ganglion cells.
Chagas' disease: selective affinity and cytotoxicity of Trypanosoma cruzi-immune lymphocytes to parasympathetic ganglion cells.
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恰加斯病：克氏锥虫免疫淋巴细胞对副交感神经节细胞的选择性亲和力和细胞毒性。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
A. Teixeira
中科院分区：
文献类型：
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作者：
M. Teixeira;Jofre Rezende Filho;Florêncio Figueredo;A. Teixeira
南美洲流行的巨食症和巨结肠与恰加斯病有关。这些巨型疾病是在慢性恰加斯氏病患者身上发现的，当时在皮损中没有明显的寄生虫。这些疾病的特征是副交感神经节细胞数量减少，内脏扩张肥大。在这里描述的实验中，我们展示了锥虫免疫淋巴细胞对肌间、副交感神经节细胞的选择性亲和力和粘附性，从而导致神经溶解。当使用来自对照兔的非免疫淋巴细胞时，或者当免疫淋巴细胞被允许与中枢神经系统神经元反应时，这些特征都没有观察到。这一证明表明，恰加斯病患者副交感神经元的破坏具有高度的特异性。我们推测，副交感神经元的克氏锥虫免疫淋巴细胞排斥反应可能与识别仅由靶神经元分泌的交叉反应抗原决定簇有关。支持这一解释的是，在没有脑炎的慢性查加斯感染中，观察到淋巴细胞渗入和副交感神经节细胞破坏。
The megaesophagus and megacolon endemic in South America are related , to Chagas' disease. These mega conditions are found in patients with chronic Chagas's infection, when the parasite is not demonstrable in the lesions. These are characterized by depopulation of parasympathetic ganglion cells, dilation and hypertrophy of the viscera. In the experiments described here we deminstrate a selective affinity and adherence of Trypanosoma cruzi-immune lymphocytes to myenteric, parasympathetic ganglion cells, leading to neuronolysis. None of these features are observed when non-immune lymphocytes from control rabbits are used, or when the immune lymphocytes are allowed to react with CNS neurons. This demonstration is an indication of the high degree of specificity of the destruction of parasympathetic neurons in Chagas' disease. We postulate that the T. cruzi-immune lymphocyte rejection of parasympathetic neurons, but not of CNS neurons, might be related to recognition of a cross-reacting antigenic determinant secreted only by the target neurons. In favor of this interpretation is the observation of lymphocytic infiltrates and parasympathetic ganglion cell destruction in chronic Chagas' infection in the absence of encephalitis.