A video-based measure to identify autism risk in infancy.
A video-based measure to identify autism risk in infancy.
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一种基于视频的方法，用于识别婴儿期自闭症风险。
DOI：
10.1111/jcpp.13105
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Ozonoff,Sally
中科院分区：
文献类型：
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作者：
Young,GregoryS;Constantino,JohnN;Dvorak,Simon;Belding,Ashleigh;Gangi,Devon;Hill,Alesha;Hill,Monique;Miller,Meghan;Parikh,Chandni;Schwichtenberg,AJ;Solis,Erika;Ozonoff,Sally
背景自闭症的症状出现在生命的前2年，但诊断的平均年龄远远落后。我们需要能够提高婴儿期自闭症风险检测的工具。本研究开发并测试了一种新的基于视频的方法来检测ASD在infanty.MethodsA前瞻性纵向研究的自闭症谱系障碍的风险升高或降低的儿童的心理测量学特性进行。参与者是76名患有ASD的年长兄弟姐妹和37名没有已知自闭症家族史的婴儿。自闭症视频参考婴儿评级系统（VIRSA）是一个基于网络的应用程序，它呈现父母和婴儿一起玩耍的成对视频，并要求强制选择判断哪个视频与正在评级的儿童最相似。父母在6个月、9个月、12个月和18个月时对VIRSA的参与者进行评分。我们检查了分半和重测信度;收敛和判别效度;敏感性，特异性，阴性和阳性预测值为并发和36个月的ASD diagnosis.ResultsThe VIRSA表现出令人满意的可靠性和收敛和判别效度。最终诊断为ASD的儿童的VIRSA评分显着低于12个月大时具有典型发育的儿童。VIRSA评分在18个月确定所有儿童诊断为ASD在该年龄段，以及78%的儿童诊断为36 months.ConclusionsThis研究代表了一个新的视频为基础的方法来检测ASD在婴儿期发展的第一步。VIRSA的心理测量特性是有前途的父母与一个年龄较大的受影响的孩子时，但仍然必须在社区样本没有ASD家族史进行测试。如果结果被复制，那么VIRSA的低负担，基于网络的格式有可能减少社区中的差异，限制筛查。
BackgroundSigns of autism are present in the first 2 years of life, but the average age of diagnosis lags far behind. Instruments that improve detection of autism risk in infancy are needed. This study developed and tested the psychometric properties of a novel video‐based approach to detecting ASD in infancy.MethodsA prospective longitudinal study of children at elevated or lower risk for autism spectrum disorder was conducted. Participants were 76 infants with an older sibling with ASD and 37 infants with no known family history of autism. The Video‐referenced Infant Rating System for Autism (VIRSA) is a web‐based application that presents pairs of videos of parents and infants playing together and requires forced‐choice judgments of which video is most similar to the child being rated. Parents rated participants on the VIRSA at 6, 9, 12, and 18 months of age. We examined split‐half and test–retest reliability; convergent and discriminant validity; and sensitivity, specificity, and negative and positive predictive value for concurrent and 36‐month ASD diagnoses.ResultsThe VIRSA demonstrated satisfactory reliability and convergent and discriminant validity. VIRSA ratings were significantly lower for children ultimately diagnosed with ASD than children with typical development by 12 months of age. VIRSA scores at 18 months identified all children diagnosed with ASD at that age, as well as 78% of children diagnosed at 36 months.ConclusionsThis study represents an initial step in the development of a novel video‐based approach to detection of ASD in infancy. The VIRSA's psychometric properties were promising when used by parents with an older affected child, but still must be tested in community samples with no family history of ASD. If results are replicated, then the VIRSA's low‐burden, web‐based format has the potential to reduce disparities in communities with limited access to screening.