The prevalence of comorbid depression in adults with diabetes - A meta-analysis
The prevalence of comorbid depression in adults with diabetes - A meta-analysis
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DOI：
10.2337/diacare.24.6.1069
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发表时间：
2001-06-01
期刊：
影响因子：
16.2
通讯作者：
Lustman, PJ
中科院分区：
文献类型：
--
作者：
Anderson, RJ;Freedland, KE;Lustman, PJ
目的：评估成人1型或2型糖尿病患者发生临床相关抑郁症的几率和患病率。抑郁与高血糖和糖尿病并发症的风险增加有关；抑郁的缓解与血糖控制的改善有关。需要比目前可用的更准确的抑郁症患病率估计，以衡量抑郁症管理在糖尿病中的潜在影响。研究设计和方法-MEDLINE和JuncINFO数据库和出版的参考文献被用来确定报告糖尿病抑郁症患病率的研究，患病率被计算为被纳入研究中受试者综合数量加权的总平均数。我们使用X(2)统计和优势比(OR)来评估抑郁症的发生率和可能性与糖尿病类型、性别、受试者来源、抑郁症评估方法和研究设计的关系。结果：总共确定了42项符合条件的研究；20项(48%)包括非糖尿病对照组。在对照研究中，糖尿病组患抑郁症的几率是非糖尿病对照组的两倍(OR=2.0，95%可信区间1.8-2.2)，并且没有性别、糖尿病类型、研究对象来源或评估方法的差异。糖尿病女性(28%)明显高于糖尿病男性(18%)，未控制组(30%)高于对照研究(21%)，临床样本(32%)高于社区样本(20%)，当通过自我报告问卷(31%)评估时，高于标准化诊断访谈(11%)。结论-糖尿病的存在使并发抑郁的几率增加一倍。患病率估计受到几个临床和方法学变量的影响，这些变量既不影响OR的稳定性，也不影响OR的稳定性。
OBJECTIVE - To estimate the odds and prevalence of clinically relevant depression in adults with type 1 or type 2 diabetes. Depression is associated with hyperglycemia and an increased risk for diabetic complications; relief of depression is associated with improved glycemic control. A more accurate estimate of depression prevalence than what is currently available is needed to gauge the potential impact of depression management in diabetes.RESEARCH DESIGN AND METHODS - MEDLINE and PsycINFO databases and published references were used to identify studies that reported the prevalence of depression in diabetes, Prevalence was calculated as an aggregate mean weighted by the combined number of subjects in the included studies. We used chi (2) statistics and odds ratios (ORs) to assess the rate and likelihood of depression as a function of type of diabetes, sex, subject source, depression assessment method, and study design.RESULTS - A total of 42 eligible studies were identified; 20 (48%) included a nondiabetic comparison group. in the controlled studies, the odds of depression in the diabetic group were twice that of the nondiabetic comparison group (OR = 2.0, 95% CI 1.8-2.2) and did not differ by sex, type of diabetes, subject source, or assessment method. The prevalence of comorbid depression was significantly higher in diabetic women (28%) than in diabetic men (18%), in uncontrolled (30%) than in controlled studies (21%), in clinical (32%) than in community (20%) samples, and when assessed by self-report questionnaires (31%) than by standardized diagnostic interviews (11%).CONCLUSIONS - The presence of diabetes doubles the odds of comorbid depression. Prevalence estimates are affected by several clinical and methodological variables that do nor affect the stability of the ORs.