The components from aerial parts of Sarcosperma affinis Gagnep. and their antibacterial activities.
The components from aerial parts of Sarcosperma affinis Gagnep. and their antibacterial activities.
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来自 Sarcosperma affinis Gagnep 地上部分的成分。
DOI：
10.1080/23312009.2016.1254421
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Ain Raal.
中科院分区：
文献类型：
--
作者：
H. T. Nguyen;D. V. Ho;V. Q. Hung;H. X. Trang;T. Kodama;T. Ito;H. Morita;Ain Raal.
从肉子草（Sarcosperma affinis Gagnep.）包括（E）-植醇（1）、十七烷-1-醇（2）、羽扇豆醇（3）、油酸（4）、3β-十六酰基油酸（5）、pomolic acid（6）、euscaphic acid（7）、myrianthic acid（8）、（+）-松醇（9）、（+）-梅曲醇（10）、（+）-姜脂素（11）、槲皮素-3-O-β-D-吡喃半乳糖苷（12）、表儿茶素（13）、邻苯二甲酸二（2-乙基己基）酯（14）、3-异戊二烯基-4-O-β-D-吡喃葡萄糖氧基-4-羟基苯甲酸（15）、淫羊藿苷E5（16）。利用1D、2D NMR、HR-ESI-MS等波谱技术对化合物进行了结构鉴定，并与文献报道的NMR数据进行了比较。其中化合物4和化合物6对耻垢分枝杆菌有较强的抗菌活性，MIC值分别为5.48和2.65 μM。本文报道了S.首次对亲和素进行了研究。
Sixteen compounds were isolated from the aerial parts ofSarcosperma affinisGagnep. including (E)-phytol (1), heptadecan-1-ol (2), lupeol (3), oleanolic acid (4), 3β-hexadecanoyloleanolic acid (5), pomolic acid (6), euscaphic acid (7), myrianthic acid (8), (+)-pinoresinol (9), (+)-medioresinol (10), (+)-syringaresinol (11), quercetin-3-O-β-D-galactopyranoside (12), epicatechin (13), bis-(2-ethylhexyl) phthalate (14), 3-prenyl-4-O-β-D-glucopyranosyloxy-4-hydroxylbenzoic acid (15), icariside E5(16). Their structures were elucidated by the combination of spectroscopy including 1D, 2D NMR, HR-ESI-MS and in comparison with the reported NMR data in the literature. Among those, compounds4and6showed potent antibacterial activity againstMycobacterium smegmatiswith MIC values of 5.48 and 2.65 μM, respectively. The chemical composition and biological activity of constituents isolated from aerial parts ofS. affiniswas studied for the first time.