Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease
Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease
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DOI：
10.1016/j.atherosclerosis.2007.08.016
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发表时间：
2008-04-01
期刊：
影响因子：
5.3
通讯作者：
Visseren, Frank L. J.
中科院分区：
文献类型：
--
作者：
Gorter, Petra M.;van Lindert, Anne S. R.;Visseren, Frank L. J.
目的：冠状动脉周围的脂肪组织可能有助于冠状动脉粥样硬化的发展，因为其局部化和局部产生炎性细胞因子的潜力。我们比较了使用心脏CT定量心外膜脂肪组织（EAT）和冠状动脉周围脂肪的各种测量方法。此外，我们估计他们的关系与肥胖和代谢综合征患者怀疑冠状动脉疾病（CAD）。方法：EAT和冠状动脉周围脂肪测量心脏多层螺旋CT扫描60例（年龄50-70岁）冠状动脉造影。EAT测量为右心室游离壁的厚度、心室底部的面积和体积。冠状动脉周围脂肪被评估为三个主要冠状动脉周围的厚度和横截面积。结果：EAT容积法测量结果重复性好，变异系数（CV）在3.0%~ 5.0%之间。EAT和冠状动脉周围脂肪厚度和面积的测量具有中等的可重复性（CV 11.0-23.4%）。EAT和冠状动脉周围脂肪的量（按标准差）与肥胖有关（BMI >= 30 kg/m（2））（β 1.24; 95% CI 0.66; 1.81）和代谢综合征（β 8 0.8 1; 95% CI 0.28; 1.33）。与EAT和冠状动脉周围脂肪厚度和面积等更简单的测量相比，使用心脏CT对EAT进行体积定量具有高度可重复性。EAT和冠状动脉周围脂肪的数量与疑似CAD患者的肥胖和代谢综合征的存在有关。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Adipose tissue surrounding coronary arteries may contribute to the development of coronary atherosclerosis given its localisation and potential for local production of inflammatory cytokines. We compared various measurements for quantifying epicardial adipose tissue (EAT) and peri-coronary fat using cardiac CT. Additionally, we estimated their relationship with obesity and metabolic syndrome in patients suspected of coronary artery disease (CAD).Methods: EAT and peri-coronary fat measurements were performed on cardiac multi-slice CT scans in 60 patients (aged 50-70 years) referred for coronary angiography. EAT was measured as thickness on the right ventricular free wall, as area at the base of the ventricles, and as volume. Peri-coronary fat was assessed as thickness and cross-sectional area surrounding the three main coronary arteries. Linear regression analysis was used to assess the relation of EAT and peri-coronary fat with obesity and metabolic syndrome (ATPIII criteria).Results: Volumetric EAT measurements showed good reproducibility with low coefficients of variation (CVs) varying between 3.0% and 5.0%. Measurements of EAT and peri-coronary fat thickness and area were moderately reproducible (CVs 11.0-23.4%). The amount of EAT and peri-coronary fat (per standard deviation) was related with obesity (BMI >= 30 kg/m(2)) (beta 1.24; 95% CI 0.66; 1.81) and metabolic syndrome (beta 8 0.8 1; 95% CI 0.28; 1.33).Conclusions: Volumetric quantification of EAT using cardiac CT is highly reproducible compared to more simple measurements as EAT and peri-coronary fat thickness and area. The quantity of EAT and peri-coronary fat is related with the presence of obesity and metabolic syndrome in patients suspected of CAD. (c) 2007 Elsevier Ireland Ltd. All rights reserved.