Understanding the prospective of nano-formulations towards the treatment of psoriasis.
Understanding the prospective of nano-formulations towards the treatment of psoriasis.
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DOI：
10.1016/j.biopha.2018.07.156
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发表时间：
2018-11
期刊：
影响因子：
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通讯作者：
M. Pradhan;A. Alexander;M. Singh;D. Singh;S. Saraf;S. Saraf;Ajazuddin
中科院分区：
文献类型：
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作者：
M. Pradhan;A. Alexander;M. Singh;D. Singh;S. Saraf;S. Saraf;Ajazuddin
银屑病是一种持续复发的炎症性自身免疫性皮肤疾病，影响约2-5%的世界人口。丰富的治疗剂可用于治疗银屑病。然而，它们中没有一个是完全安全和有效的治疗疾病，而不影响患者的依从性。此外，已经存在的药物应该抑制疾病并减轻体征和症状，而不是完全治愈。然而，他们专注于抑制疾病和缓解症状，而不是提供绝对的治愈方法。因此，仍然存在一个重要的挑战，探索一种新的药物部分或输送系统，可以安全有效地管理银屑病，而不影响患者的依从性。基于纳米载体的新型制剂通过减少剂量、给药频率、剂量依赖性、副作用和增强疗效，克服了传统制剂的局限性，具有良好的前景。目前纳米制剂已广泛应用于银屑病的有效和安全的治疗，本文主要综述了传统的治疗策略和各种抗银屑病药物的脂质纳米制剂、聚合物纳米制剂和金属纳米制剂的最新进展。详细讨论了脂质体、纳米结构脂质载体、醇质体、固体脂质纳米粒、纳米胶囊、胶束、树枝状大分子、金纳米粒和银纳米粒等各种纳米载体系统的实用性。该综述还追踪了相关专利，以确定各种纳米颗粒在银屑病治疗中的作用。简而言之，纳米制剂仍然是治疗银屑病的一种有前途的治疗方式，因为它们提出了更好的渗透性，靶向递送，增强的安全性和有效性。
Psoriasis is a consistently recurring, inflammatory, autoimmune disorder of the skin, affecting about 2–5% of the world population. Abundant therapeutic agents are accessible for the treatment of psoriasis. Nevertheless, none of them are entirely secure and effective to treat the disease without compromising patient compliance. Furthermore, already existing drugs are supposed to restrain the ailment and alleviate the sign and symptoms with no complete cure. However, they focus on restraining the disease and alleviating the symptoms without providing an absolute cure. Therefore there remains a vital challenge, to explore a new drug moiety or delivery system which could safely and effectively manage psoriasis without compromising patient compliance. Furthermore, conventional formulations offer reduced benefit/risk ratio of anti-psoriatic drugs, which limits the use of existing conventional formulations.Novel formulations based on nanocarriers are a promising prospect to overcome the limitation of conventional formulations by offering a reduction in dose, dosing frequency, dose-dependent, side effects with enhanced efficacy. Presently nano-formulations have gained widespread application for effective and safe treatment of psoriasis.The present review primarily focuses on conventional therapeutic strategy and recent advances in lipid-based, polymer-based and metallic nano-formulations of a variety of anti-psoriatic drugs. The practicability of various nanocarrier systems including liposomes, nanostructured lipid carriers, ethosomes, solid lipid nanoparticles, nanocapsules, micelles, dendrimers, gold nanoparticles and silver nanoparticles have been discussed in detail. The review also traces related patents to exemplify the role of various nanoparticles in psoriasis treatment. In a nutshell, nano-formulations remain established as a promising modality for treating psoriasis treatment as they propose better penetration, targeted delivery, enhanced safety, and efficacy.