Dendritic Cells in Autoimmune Diseases
Dendritic Cells in Autoimmune Diseases
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DOI：
10.2174/1876539401003010001
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发表时间：
2010-01
期刊：
影响因子：
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通讯作者：
M. Maddur;J. Vani;J. Dimitrov;K. N. Balaji;S. Lacroix-Desmazes;S. Kaveri;J. Bayry
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文献类型：
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作者：
M. Maddur;J. Vani;J. Dimitrov;K. N. Balaji;S. Lacroix-Desmazes;S. Kaveri;J. Bayry
树突状细胞（Dendritic cells，DC）是专职的抗原提呈细胞，在维持免疫耐受和诱导适应性免疫应答中起重要作用。因此，DC在激发自身免疫性及其维持自身免疫性疾病中是最受欢迎的。对DC、DC衍生的细胞因子和细胞内信号转导途径在介导自身免疫性疾病和产生炎性增强中的重要性的新认识为寻求阻断这些炎性途径以用于治疗目的的策略提供了理论基础。
Dendritic cells (DCs) are professional antigen presenting cells, which play a crucial role both in maintaining immune tolerance and in inducing adaptive immune responses. Therefore, DCs are the most sought in inciting autoimmu- nity and its sustenance to autoimmune diseases. The emerging knowledge of the importance of DCs, DC-derived cytoki- nes, and intracellular signal transduction pathways in mediating autoimmune diseases and in creating an inflammatory en- vironment provides a rationale for pursuing strategies to block these inflammatory pathways for therapeutic purposes.