A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies.
A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies.
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DOI：
10.1016/j.artres.2015.11.001
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发表时间：
2016-03
期刊：
影响因子：
0.6
通讯作者：
Weber T
中科院分区：
文献类型：
--
作者：
Akhtar R;Cruickshank JK;Zhao X;Derby B;Weber T
本研究探讨了使用扫描声学显微镜（SAM）作为主动脉活检表征动脉僵硬的潜在工具。本文介绍了在多支冠状动脉疾病的主动脉搭桥手术中收集的人体组织的SAM数据。将由SAM测定的声波速度与患者的临床数据即脉搏波速度（PWV）、血压、胆固醇和葡萄糖水平进行比较。声速与PWV值无明显关系，收缩压、舒张压与声速呈反比关系。然而，在胆固醇或葡萄糖水平较高的患者中，声波速度增加。需要更详细的调查将SAM数据与临床测量联系起来。扫描声学显微镜（SAM）是一种潜在的动脉硬度检测工具。SAM提供了一种测量声波速度的方法。在这个初步研究中，没有观察到脉冲波速度的明显趋势。血压与声速呈负相关。观察其他临床指标如葡萄糖和总胆固醇的趋势。
This study explores the use of scanning acoustic microscopy (SAM) as a potential tool for characterisation of arterial stiffness using aortic biopsies. SAM data is presented for human tissue collected during aortic bypass graft surgery for multi-vessel coronary artery disease. Acoustic wave speed as determined by SAM was compared to clinical data for the patients namely, pulse wave velocity (PWV), blood pressure, cholesterol and glucose levels. There was no obvious trend relating acoustic wave speed to PWV values, and an inverse relationship was found between systolic and diastolic blood pressure and acoustic wave speed. However, in patients with a higher cholesterol or glucose level, the acoustic wave speed increased. A more detailed investigation is needed to relate SAM data to clinical measurements. Scanning acoustic microscopy (SAM) is a potential tool for arterial stiffness. SAM provides a measure of the acoustic wave speed. In this pilot study, no clear trend was observed with pulse wave velocity. Blood pressure was inversely related with acoustic wave speed. Trends observed with other clinical markers such as glucose and total cholesterol.