Therapy of secondary acute nonlymphocytic leukemia with cytarabine.

Therapy of secondary acute nonlymphocytic leukemia with cytarabine.
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阿糖胞苷治疗继发性急性非淋巴细胞白血病。

DOI:
10.1056/nejm198301063080105
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发表时间:
1983
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
Browman,G
Browman,G
中科院分区:
--
文献类型:
--
作者:
Preisler,HD;Early,AP;Raza,A;Vlahides,G;Marinello,MJ;Stein,AM;Browman,G

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急性非淋巴细胞性白血病是一种越来越常见的烷化剂或电离辐射治疗的并发症。据报道,在接受联合治疗的霍奇金病患者中,继发性白血病的发生率高达5%。1在接受烷化剂治疗的多发性骨髓瘤、2卵巢癌和乳腺癌患者中,继发性白血病越来越常见。与“原发性”急性非淋巴细胞白血病患者不同,继发性白血病患者很少对常规诱导缓解方案有反应。据报道,诱导缓解率约为10%,中位生存期为......
ACUTE nonlymphocytic leukemia is an increasingly common complication of therapy with alkylating agents or ionizing radiation. Incidences as high as 5 per cent have been reported in patents with Hodgkin's disease who were treated with combined-modality therapy.1Secondary leukemias are becoming increasingly common in patients treated with alkylating agents for multiple myeloma,2ovarian carcinoma, and carcinoma of the breast. Unlike patients with "primary" acute nonlymphocytic leukemia, those with the secondary form of the disease rarely respond to conventional regimens for inducing remission. Reported rates of remission induction are in the neighborhood of 10 per cent, with median survival periods of . . .
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DOI: --
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