Dynamic contrast-enhanced MRI using Gd-DTPA: Interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors
Dynamic contrast-enhanced MRI using Gd-DTPA: Interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors
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DOI：
10.1002/mrm.1137
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发表时间：
2001-06-01
影响因子：
3.3
通讯作者：
Brix, G
中科院分区：
文献类型：
--
作者：
Port, RE;Knopp, MV;Brix, G
应用动态MRI对47例乳腺良、恶性肿瘤患者的动脉血流动力学进行了研究。信号增强监测10分钟后开始的1分钟输注的0.1 mmol/kg Gd-DTPA。血液中的动力学为双指数，中位半衰期分别为21秒和11.1分钟。峰值信号增强和信号增强-时间曲线下面积在患者之间变化2.5倍和3.7倍。使用个体（参考）或平均群体（替代）动脉输入函数（AIF）估计最多三个肿瘤隔室之一的最短平均停留时间MRT*。癌、纤维腺瘤和乳腺癌的MRT*（参考估计值）分别为1.0（0-1.5）、1.9（1.5-2.3）和2.5（2.3-2.8）min（中位数和四分位数间距）。替代估计值是无偏的，但在23%的情况下与参考估计值相差1.5倍或更多。如果需要准确估计个体MRT*，则应单独监测AIF。(C)2001 Wiley-Liss，Inc.
Gd-DTPA kinetics in arterial brood was investigated by dynamic MRI in 47 patients with malignant and benign mammary tumors. Signal enhancement was monitored for 10 min after the beginning of a 1-min infusion of 0.1 mmol/kg Gd-DTPA. Kinetics in blood was biexponential with median half-lives of 21 sec and 11.1 min, respectively. Peak signal enhancement and the area under the signal enhancement-time curve varied 2,5- and 3.7-fold between patients. The shortest mean residence time in one of up to three tumor compartments, MRT*, was estimated using either the individual (reference) or a mean population (surrogate) arterial input function (AIF). MRT* (reference estimate) was 1.0 (0-1.5), 1.9 (1.5-2.3), and 2.5 (2.3-2.8) min in carcinomas, fibroadenomas, and mastopathies, respectively (median and interquartile distance). Surrogate estimates were unbiased but differed from the reference estimates 1.5-fold or more in 23% of cases. AIFs should be monitored individually if accurate estimates of individual MRT* are desired. (C) 2001 Wiley-Liss, Inc.