Serum 25-Hydroxyvitamin D associated with indicators of body fat and insulin resistance in prepubertal chilean children
Serum 25-Hydroxyvitamin D associated with indicators of body fat and insulin resistance in prepubertal chilean children
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DOI：
10.1038/ijo.2015.148
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Uauy, R.
中科院分区：
文献类型：
--
作者：
Cediel, G.;Corvalan, C.;Uauy, R.
背景技术背景：结论：（1）血清25-羟基维生素D [25（OH）D]与肥胖、胰岛素抵抗（IR）、胰岛素抵抗（IR（2）评估血清25（OH）D的临界值，该临界值最能反映儿童的IR、总脂肪和中心脂肪。青春期前儿童对来自生长和肥胖智利队列研究的435名儿童（53%为女孩，7岁为女孩）的血清25（OH）D与以下指标之间的潜在相关性进行了评价：（1）总肥胖（按年龄划分的体重指数（BAZ）、体脂（包括三组分模型）、中心性肥胖（腰围和躯干肥胖）;（2）IR（IR的稳态模型评估）和胰岛素敏感性（定量胰岛素敏感性检查指数）使用具有标准化系数和受试者工作特征曲线的标准化多元回归模型。总体而言，平均血清25（OH）D为32.1 +/- 9.2 ng ml（-1），而19.4%的儿童肥胖（BAZ >= 2 s.d.）。血清25（OH）D与总脂肪和中心性脂肪指标以及IR指标呈负相关。女孩的效应量中等（肥胖和IR指标的效应量为0.3），而男孩的效应量较弱。血清25（OH）D最佳预测总肥胖、中心性肥胖和IR的临界值接近30 ng ml（-1）。血清25（OH）D低于最佳水平（= 30 ng ml（-1））的儿童足以评估该年龄组的肥胖和IR风险。
BACKGROUND: Consistent data on the relation between vitamin D, body fat and insulin resistance (IR) in children are lacking.OBJECTIVES: (1) To evaluate the association between serum 25-Hydroxyvitamin D [25(OH) D] and key indicators of: adiposity (total and central), IR, and (2) to estimate serum 25(OH) D cut-offs that best reflect IR and total and central adiposity in children.SUBJECTS/METHODS: Prepubertal children (n = 435, similar to 53% girls; similar to age 7 years) from the Growth and Obesity Chilean Cohort Study were evaluated for potential associations between serum 25(OH) D and indicators of: (1) total adiposity (body mass index by age (BAZ), body fat (including three-component model)), central adiposity (waist circumference and trunk fatness); (2) IR (homeostasis model assessment of IR) and insulin sensitive (quantitative insulin sensitivity check index) using standardized multiple regression models with standardized coefficients and receiver operating characteristic curves.RESULTS: Overall, mean serum 25(OH)D was 32.1 +/- 9.2 ng ml(-1), while 19.4% of children were obese (BAZ >= 2 s.d.). Serum 25(OH)D was inversely associated with indicators of total and central adiposity and with IR indicators. Effect sizes were moderate in girls (similar to 0.3 for adiposity and IR indicators), while, weaker values were found in boys. Serum 25(OH)D estimated cut-offs that best predicted total, central adiposity and IR were similar to 30 ng ml(-1). Children with suboptimal serum 25(OH)D (= 30 ng ml(-1)) was adequate to assess obesity and IR risk in this age group.