Proportion of reflux esophagitis in 6010 Japanese adults: prospective evaluation by endoscopy
Proportion of reflux esophagitis in 6010 Japanese adults: prospective evaluation by endoscopy
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DOI：
10.1007/s005350050293
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发表时间：
1999-08-01
影响因子：
6.3
通讯作者：
Fujimoto, K
中科院分区：
文献类型：
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作者：
Furukawa, N;Iwakiri, R;Fujimoto, K
与西方国家的研究结果相比，东方国家的反流性食管炎的患病率估计较低。在这项前瞻性研究中，我们旨在通过内窥镜检查检查日本成年人中反流性食管炎的比例。根据洛杉矶食管炎分类，在所有接受内窥镜检查的受试者中，内窥镜医生被前瞻性地指导对合并食管炎的食道黏膜损伤进行分级。从1996年12月到1998年2月，共有6010名受试者接受了内窥镜检查以评估食管炎的分级。受试者包括4394名没有接受胃肠道疾病药物治疗的门诊患者和1616名来医院进行常规体检的受试者。食管炎的总比例为16.3%。大多数食管炎患者为A级或B级(A级和B级的比例分别为9.6%和4.6%)。年龄相关的食管炎和严重食管炎(即C级和D级)的比例在70岁以上的女性和80岁以上的男性中有所增加。体重指数增加(部分原因是骨质疏松症导致身高降低)和/或裂孔突出，与70岁以上女性食管炎的比例有关。这些数据表明反流性食管炎在日本是一种常见病。然而，严重的食管炎(C级和D级)并不常见。
Compared with findings in Western countries, the prevalence of reflux esophagitis in Oriental countries is estimated to be low. In this prospective study, we aimed to examine the proportion of reflux esophagitis in Japanese adults, as evaluated by endoscopy. Endoscopists were prospectively directed to grade esophageal mucosal breaks with esophagitis according to the Los Angeles Classification of Esophagitis in all subjects that underwent endoscopic examination. In total, 6010 subjects underwent endoscopic examination for evaluation of esophagitis grading from December 1996 to February 1998. The subjects included 4394 outpatients who were not receiving medication for gastrointestinal disease and 1616 subjects who visited the hospital for routine physical examinations. The overall proportion of esophagitis was 16.3%. Most of the subjects with esophagitis were classified as having grade A or B (proportion of grades A and B; 9.6% and 4.6%, respectively). The age-related proportion of esophagitis and of severe esophagitis (i.e., grades C and D) increased in females aged over 70 and in males aged over 80. Increased body mass index (partly due to decreased height caused by osteoporosis), and/or hiatal herniation, were related to the proportion of esophagitis in females aged over 70. These data indicated that reflux esophagitis is a common disease in Japan. However, severe esophagitis (grades C and D) is not common.