VOLUNTARY EXERCISE INDUCES STRUCTURAL REMODELING IN THE HEARTS OF DYSTROPHIN-DEFICIENT MICE
VOLUNTARY EXERCISE INDUCES STRUCTURAL REMODELING IN THE HEARTS OF DYSTROPHIN-DEFICIENT MICE
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DOI：
10.1002/mus.21783
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发表时间：
2010-12-01
期刊：
影响因子：
3.4
通讯作者：
Plochocki, Jeffrey H.
中科院分区：
文献类型：
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作者：
Costas, Jeffrey M.;Nye, David J.;Plochocki, Jeffrey H.
在这项探索性研究中，我们检验了这样的假设：自愿运动会影响心脏左心室营养不良变化的进展。将 7 周龄的野生型 (C57BL/10ScSn) 和抗肌营养不良蛋白缺陷 (mdx) 小鼠分为久坐组和运动治疗组，并测试心脏组织形态计量学的差异。研究发现，与久坐的 mdx 小鼠相比，运动的 mdx 小鼠的心室显着扩大且侧脑室壁更薄（P < 0.05）。三色染色表明 20% 的 mdx 运动组左心室心肌存在纤维化病变。在对照或久坐的 mdx 小鼠中未发现纤维化病变。野生型小鼠的治疗组之间没有发现组织形态学差异。我们的研究结果表明，自愿运动可能会加速年轻 mdx 小鼠心室扩张和纤维化的进展。在抗肌营养不良蛋白缺乏患者的心脏病治疗过程中，应考虑运动对心脏重塑的影响。肌肉神经 42：881-885，2010
In this exploratory study, we test the hypothesis that voluntary exercise affects the progression of dystrophic changes in the left ventricle of the heart. Wild-type (C57BL/10ScSn) and dystrophin-deficient (mdx) mice, aged 7 weeks, were divided into sedentary and exercise-treated groups and tested for differences in cardiac histomorphometry. Exercised mdx mice were found to exhibit significantly enlarged ventricles and thinner lateral ventricular walls than sedentary mdx mice (P < 0.05). Trichrome staining indicated the presence of fibrotic lesions in the left ventricular myocardium in 20% of the exercised mdx group. Fibrotic lesions were not found in control or sedentary mdx mice. No histomorphometric differences were found between treatment groups in wild-type mice. Our findings suggest voluntary exercise may accelerate the progression of ventricular dilation and fibrosis in young mdx mice. The effects of exercise on cardiac remodeling should be considered during the treatment of cardiac disease in dystrophin-deficient patients. Muscle Nerve 42: 881-885, 2010