Beware of cells bearing gifts: cell replacement therapy and arrhythmic risk.
Beware of cells bearing gifts: cell replacement therapy and arrhythmic risk.
复制标题
谨防细胞带来的礼物：细胞替代疗法和心律失常的风险。
DOI：
10.1161/01.res.00000175827.99824.7f
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发表时间：
2005
影响因子：
20.1
通讯作者：
DudleyJr,SamuelC
中科院分区：
文献类型：
--
作者：
DudleyJr,SamuelC
心力衰竭是一个主要的全球性健康问题，尽管最近的治疗进展，但其患病率仍在增长。心力衰竭患者最终死于泵衰竭或心律失常，收缩功能障碍的程度与心脏病风险之间存在联系。自20世纪60年代以来，心力衰竭的最终治疗方法一直是心脏移植，但器官供应有限限制了这种治疗的影响。从20世纪90年代中期开始，一系列的观察导致了细胞可能用于修复心肌损伤的概念。随后，这种疗法在缺血性和非缺血性心肌损伤中显示出前景。
Heart failure is a major worldwide health problem that is growing in prevalence despite recent treatment advances. Patients with heart failure ultimately die from either pump failure or cardiac arrhythmia, and there is a link between the degree of contractile dysfunction and arrhythmic risk. Since the 1960s, the definitive therapy for heart failure has been cardiac transplantation, but the limited supply of organs has restricted the impact of this therapy. Starting in the mid-1990s, a series of observations has led to the concept that cells might be used to repair myocardial damage. Subsequently, this therapy has shown promise in ischemic and nonischemic forms of myocardial injury.