Chronic mild stress has no effect on responding by rats for sucrose under a progressive ratio schedule
Chronic mild stress has no effect on responding by rats for sucrose under a progressive ratio schedule
复制标题
DOI：
10.1016/s0031-9384(98)00060-2
复制
发表时间：
1998-07-01
影响因子：
2.9
通讯作者：
Phillips, AG
中科院分区：
文献类型：
--
作者：
Barr, AM;Phillips, AG
大鼠暴露于慢性不可预测的轻度应激（CMS）已被证明会产生一种综合征，其中广泛的完成行为减弱，类似于快感缺乏的状态，这可能会通过抗抑郁药物治疗逆转。本研究的目的是确定CMS是否也会影响大鼠的动机，以响应蔗糖溶液，其性能下的渐进比（PR）的时间表的强化评估。对照研究表明，非应激大鼠的断点对所用蔗糖溶液的浓度以及测试前所用的食物和水剥夺时间敏感。大鼠暴露于CMS后，在1%或7%蔗糖溶液的渐进比例方案下响应时，对断点没有影响，尽管受试者确实显示出自由消耗的1%蔗糖溶液的消耗量的典型减少。这些结果是不容易理解的CMS模型的快感缺乏的理论框架内，而不是暗示，神经和心理相关的动机可能是不太容易受到调制的影响CMS比免费消费的甜的解决方案。(C)1998年爱思唯尔科学公司
Exposure of rats to chronic unpredictable mild stress (CMS) has been shown to produce a syndrome in which a wide range of consummatory behaviors are attenuated, resembling a state of anhedonia, which may be reversed by treatment with antidepressant drugs. The aim of the present study was to determine whether CMS would also affect a rat's motivation to respond for a sucrose solution, as assessed by its performance under a progressive ratio (PR) schedule of reinforcement. Control studies demonstrated that break points in nonstressed rats were sensitive to both the concentration of sucrose solution used, as well as the period of food and water deprivation used prior to testing. Exposure of rats to CMS had no effect upon break points when responding under a progressive ratio schedule for either a 1% or 7% sucrose solution, although subjects did display the typical reduction in consumption of a freely consumed 1% sucrose solution. These results are not readily understood within the theoretical framework of the CMS model of anhedonia and imply instead that both the neural and psychological correlates of motivation may be less susceptible to modulation by the effects of CMS than the free consumption of sweet solutions. (C) 1998 Elsevier Science Inc.