An Association Study on Renalase Polymorphisms and Ischemic Stroke in a Chinese Population
An Association Study on Renalase Polymorphisms and Ischemic Stroke in a Chinese Population
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中国人群肾酶多态性与缺血性脑卒中的关联研究
DOI：
10.1007/s12017-013-8227-0
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发表时间：
2013-06-01
影响因子：
3.5
通讯作者：
Fu, Songbin
中科院分区：
文献类型：
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作者：
Zhang, Ruyou;Li, Xiaoying;Fu, Songbin
缺血性中风是全球死亡和成人残疾的主要原因。最近的研究表明，肾酶与心脏病和高血压密切相关，并可能在缺血性卒中中发挥作用。在这项研究中，我们调查肾酶和缺血性中风之间的遗传关联在北方中国汉族人群。我们对来自中国北方汉族人群的507名缺血性卒中患者和503名性别匹配的对照者的肾酶基因单核苷酸多态性进行了基因分型，并根据糖尿病或高血压并发症和缺血性卒中亚型对这些病例样本进行了深入分类。我们在所有病例和亚组中进行了等位基因、基因型和单体型关联研究，并通过logistic回归进行了多因素分析。通过logistic回归分析，rs 10887800和rs 2576178与缺血性卒中伴高血压显著相关（分别为p= 0.041和p = 0.038）。隐性模型显示rs 2296545与高血压亚组中缺血性脑卒中患者有较强的相关性（OR = 1.927，95%CI = 1.012- 3.669，p = 0.046）。肾酶基因与中国北方汉族人群缺血性卒中密切相关，提示肾酶可能在脑卒中病理机制中起作用。
Ischemic stroke is a leading cause of death and adult disability worldwide. Recent research suggests that renalase is strongly associated with heart disease and hypertension and may play a role in ischemic stroke. In this study, we investigate the genetic association between renalase and ischemic stroke in a northern Chinese Han population. We genotyped single-nucleotide polymorphisms of the renalase gene in 507 ischemic stroke patients and 503 gender-matched controls from a northern Chinese Han population, and we classified these case samples in depth by complications with diabetes or hypertension and by ischemic stroke subtypes. We undertook allele, genotype, and haplotype association studies in all the cases and in the subgroups, as well as multiple factor analysis by logistic regression. rs10887800 and rs2576178 were significantly associated with ischemic stroke with hypertension by logistic regression (p= 0.041 andp= 0.038, respectively). The recessive model showed a strong association of rs2296545 with ischemic stroke patients in hypertension subgroups (OR = 1.927, 95 % CI = 1.012–3.669,p= 0.046). The renalase gene is closely related to ischemic stroke in this northern Chinese Han population, suggesting that renalase may be mechanistically involved in stroke pathology.