Obstructive sleep apnea in obese minipigs.
Obstructive sleep apnea in obese minipigs.
复制标题
DOI：
10.15761/jts.1000374
复制
发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Liu ZJ
中科院分区：
文献类型：
--
作者：
Deng MZ;Abdelfattah MY;Baldwin MC;Weaver EM;Liu ZJ
肥胖已经达到流行的程度，是阻塞性睡眠呼吸暂停(OSA)的强烈风险因素。然而，其潜在的机制尚不清楚，目前针对阻塞性睡眠呼吸暂停综合征和肥胖症的治疗策略存在严重的局限性。因此，建立自发性阻塞性睡眠呼吸暂停的肥胖相关大型动物模型势在必行。监测了4只肥胖(BMI>；48)和3只非肥胖(BMI<；40)小型猪的自然睡眠和镇静睡眠。这些小型猪在镇静状态下使用生物无线电系统，无线记录呼吸气流、鼾声、腹部和胸部呼吸运动、脑电、脑电、肌电和血氧饱和度。仪器安装完成后，这些小型猪被放在一个黑暗的房间里，房间里有一个远程夜视摄像头，用来监控所有的行为。对清醒和不同睡眠阶段进行了分类，并确定了自然睡眠和/或镇静睡眠期间的呼吸暂停和/或低呼吸发作。在两只非肥胖的小型猪中没有观察到低呼吸事件，但一只非肥胖的小型猪有5次低呼吸事件。在所有4只肥胖小型猪中都发现了严重的鼾声和27-58次呼吸暂停和/或低呼吸暂停发作。这些发作大多发生在尤卡坦小型猪的自然睡眠和/或镇静睡眠期间的快速眼动阶段。肥胖的小型猪可以体验到自然发生的OSA，因此是研究肥胖相关OSA的理想大动物模型。
Obesity has reached epidemic proportions and is a strong risk factor for obstructive sleep apnea (OSA). However, the underlying mechanisms are poorly understood and current treatment strategies for OSA and obesity have critical limitations. Thus, establishment of an obesity-related large animal model with spontaneous OSA is imperative. Natural and sedated sleep were monitored and characterized in 4 obese (body mass index - BMI>48) and 3 non-obese (BMI<40) minipigs. These minipigs were instrumented with the BioRadio system under sedation for the wireless recording of respiratory airflow, snoring, abdominal and chest respiratory movements, electroencephalogram, electrooclulogram, electromyogram, and oxygen saturation. After instrumentation, the minipigs were placed in a dark room with a remote night-vision camera for monitoring all behaviors. Wakefulness and different sleep stages were classified, and episodes of apneas and/or hypopneas were identified during natural and/or sedated sleep. No hypopnea episodes were observed in two of the non-obese minipigs, but one non-obese minipig had 5 hypopnea events. Heavy snoring and 27-58 apnea and/or hypopnea episodes were identified in all 4 obese minipigs. Most of these episodes occurred in the rapid eye movement stage during natural sleep and/or sedated sleep in Yucatan minipigs. Obese minipigs can experience naturally occurring OSA, thus are an ideal large animal model for obese-related OSA studies.