DEVELOPMENTAL GENETICS OF THE MECHANOSENSORY NEURONS OF CAENORHABDITIS-ELEGANS
DEVELOPMENTAL GENETICS OF THE MECHANOSENSORY NEURONS OF CAENORHABDITIS-ELEGANS
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DOI：
10.1016/0012-1606(81)90459-0
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发表时间：
1981-01-01
影响因子：
2.7
通讯作者：
SULSTON, J
中科院分区：
文献类型：
--
作者：
CHALFIE, M;SULSTON, J
线虫C. elegans是由一组6个感觉神经元，微管细胞，良好表征的解剖和连接介导的。当这些细胞被激光显微手术杀死时，正常的触摸反应被消除。鉴定微管细胞作为触觉敏感性的介质允许检查突变对这些细胞的发育和分化的影响。分离出接触不敏感突变体[42]。它们分为13个互补组。5个互补组中的突变对微管细胞具有明显的影响。这些表型包括特征性细胞超微结构的改变、神经元突起生长的缺失和细胞的缺失（通过产生细胞的细胞分裂模式的改变或通过现有细胞的变性或死亡）。似乎很少有基因影响这类细胞的生长和功能，而其他细胞则没有，这可能是因为主要影响微管细胞的基因达到了饱和水平。
Touch sensitivity in the nematode C. elegans is mediated by a set of 6 sensory neurons, the microtubule cells, of well-characterized anatomy and connectivity. The normal touch response is eliminated when these cells are killed by laser microsurgery. The identification of the microtubule cells as the mediators of touch sensitivity permits examination of the effects of mutations on the development and differentiation of these cells. Touch-insensitive mutants [42] were isolated. These fall into 13 complementation groups. Mutations in 5 of the complementation groups have recognizable effects on the microtubule cells. These phenotypes include alterations of characteristic cellular ultrastructure, absence of neuronal process growth and the absence of the cell (either by alterations in the patterns of cell division that produce the cells or by degeneration or death of existing cells). Few genes appear to affect the growth and function of this class of cells and no others, possibly because the genes primarily affecting the microtubule cells are reaching their saturation level.