Reversible Formation of Nanoparticles by Thermoresponsive Dehydroalanine Polymer: Poly(N-isobutyryldehydroalanine methyl ester)
Reversible Formation of Nanoparticles by Thermoresponsive Dehydroalanine Polymer: Poly(N-isobutyryldehydroalanine methyl ester)
复制标题
热响应性脱氢丙氨酸聚合物：聚(N-异丁酰脱氢丙氨酸甲酯)可逆形成纳米粒子
DOI：
10.1246/cl.2002.184
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发表时间：
2002
影响因子：
1.6
通讯作者：
Hitoshi Tanaka
中科院分区：
文献类型：
--
作者：
Y. Tezuka;Y. Bando;Hitoshi Tanaka
合成了N-异丁酰基脱氢丙氨酸(IBDHA)及其甲酯(IBDHAM)两种脱氢丙氨酸单体，并用自由基聚合法制备了它们的均聚物。聚(IBDHA)在水中没有发生任何相变，而聚(IBDHAM)在19℃时表现出较低的临界溶解温度(LCST)，在临界溶解温度(LCST)之上形成了直径为60 nm的纳米胶体分散体。这种纳米颗粒的形成是热可逆的。
Two kinds of dehydroalanine monomers, N-isobutyryl dehydroalanine (iBDHA) and its methyl ester (iBDHAM), were synthesized and their homopolymers were prepared by free radical polymerization. While poly(iBDHA) did not show any phase transition in water, poly(iBDHAM) exhibited the lower critical solution temperature (LCST) at 19 °C to form colloidal dispersion of nanoparticles with 60 nm diameter above the LCST. This nanoparticle formation was thermoreversible.