Synergism between poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan and cefazolin in prophylaxis of staphylococcal wound infection in a guinea pig model.
Synergism between poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan and cefazolin in prophylaxis of staphylococcal wound infection in a guinea pig model.
复制标题
聚-(1-6)-β-D-吡喃葡萄糖基-(1-3)-β-D-吡喃葡萄糖葡聚糖和头孢唑啉在预防豚鼠模型中葡萄球菌伤口感染中的协同作用。
DOI：
10.1128/aac.42.9.2449
复制
发表时间：
1998
影响因子：
4.9
通讯作者：
Kernodle,DS
中科院分区：
文献类型：
--
作者：
Kaiser,AB;Kernodle,DS
To determine whether the infection-preventing capability of the neutrophil-activating agent poly-(1-6)-β-d-glucopyranosyl-(1-3)-β-d-glucopyranose glucan (PGG-glucan) can be enhanced with antibiotic prophylaxis, we administered PGG-glucan and cefazolin, alone and in combination, to guinea pigs inoculated with isolates of staphylococci. Guinea pigs receiving both PGG-glucan and cefazolin had 50% infective doses that were 8- to 20-fold higher than those obtained with cefazolin alone and 100- to 200-fold higher than those obtained with PGG-glucan alone. PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.
