Aneuploidy and cancer
Aneuploidy and cancer
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DOI：
10.1038/nature03099
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发表时间：
2004-11-18
期刊：
影响因子：
64.8
通讯作者：
Lengauer, C
中科院分区：
文献类型：
--
作者：
Rajagopalan, H;Lengauer, C
与正常细胞相反，非整倍性-染色体数量的改变-几乎在所有癌症中都能观察到。越来越多的证据表明，非整倍体通常是由一种特殊类型的遗传不稳定性引起的，称为染色体不稳定性，这可能反映了癌细胞中有丝分裂分离的缺陷。更好地了解导致非整倍体的分子机制，有望开发针对这一过程的癌症药物。
In contrast to normal cells, aneuploidy - alterations in the number of chromosomes - is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.