The Epigenetics of Intrauterine Smoke Exposure: Can Maternal Vitamin C Supplementation Prevent Neonatal Respiratory Disease?
The Epigenetics of Intrauterine Smoke Exposure: Can Maternal Vitamin C Supplementation Prevent Neonatal Respiratory Disease?
复制标题
宫内烟雾暴露的表观遗传学：母亲补充维生素 C 能否预防新生儿呼吸道疾病？
DOI：
10.1164/rccm.201705-0856ed
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发表时间：
2017
影响因子：
24.7
通讯作者：
Sharma,Sunita
中科院分区：
文献类型：
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作者：
Sharma,Sunita
IUS暴露以前与人胎肺（5）、胎盘（5，6）、新生儿脐带血（7-11）和儿童颊粘膜（12）中DNA甲基化的变化相关。先前的研究还确定，新生儿中鉴定的DNA甲基化变化存在剂量-反应关系，这取决于宫内暴露的持续时间和强度，并且IUS暴露导致的许多DNA甲基化修饰持续到青春期（10）。维生素C是人体必需的维生素，具有抗氧化特性，是DNA甲基化的重要辅助因子。在正常发育过程中，胎儿血浆中的维生素C浓度高于母体水平，这表明它可能对发育中的胎儿特别重要（13）。已知香烟烟雾暴露会降低血浆维生素C水平（14），这通常是怀孕吸烟者缺乏的（15）。动物模型已经证明，怀孕期间补充维生素C可以改善产前尼古丁暴露对新生儿肺功能的影响（16）。此外，最近的一项小型随机对照试验表明，孕妇吸烟者补充维生素C与新生儿肺功能改善和1年时喘息减少有关（15）。然而，维生素C补充剂对吸烟母亲的新生儿DNA甲基化模式的影响尚不清楚，这可能有助于了解维生素C补充剂在新生儿呼吸结局中的作用。
IUS exposure has been previously associated with changes in DNA methylation in human fetal lung (5), placenta (5, 6), newborn cord blood (7–11), and the buccal mucosa of children (12). Previous studies have also established that there is a dose–response relationship to the DNA methylation changes identified in the newborn that is dependent on the duration and intensity of the intrauterine exposure and that many of these DNA methylation modifications that result from IUS exposure persist into adolescence (10).Vitamin C, an essential vitamin in humans, with antioxidant properties, is an important cofactor in DNA methylation. During normal development, fetal vitamin C concentrations in the plasma are higher than maternal levels, suggesting that it may be of particular importance to the developing fetus (13). Cigarette smoke exposure is known to decrease plasma vitamin C levels (14), which are commonly deficient in pregnant smokers (15). Animal models have demonstrated that vitamin C supplementation during pregnancy ameliorates the effect of prenatal nicotine exposure on pulmonary function in newborns (16). Furthermore, a recent small randomized controlled trial demonstrated that vitamin C supplementation in pregnant smokers was associated with improved measures of pulmonary function in the newborn and in decreased wheeze at 1 year (15). However, the impact of vitamin C supplementation on the DNA methylation patterns in the newborns of smoking mothers is unknown and may provide insight into the role of vitamin C supplementation in respiratory outcomes of the newborn.