Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke
Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke
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DOI：
10.1016/j.jocn.2020.02.016
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发表时间：
2020-03-01
影响因子：
2
通讯作者：
Koh, Seong-Ho
中科院分区：
文献类型：
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作者：
Kwon, Hyuk Sung;Lee, Eun-Hye;Koh, Seong-Ho
可溶性触发受体表达于髓样细胞2 （Soluble trigger receptor expression on myeloid cells 2, sTREM2）是由TREM2的裂解而来，表达于microlgia和其他组织特异性巨噬细胞的细胞表面。在本研究中，我们评估了缺血性脑卒中（IS）后sTREM2水平的变化及其与临床预后的关系。2011年6月至2014年5月共纳入43例诊断为非心源性IS的患者。排除静脉溶栓或动脉内取栓的患者。驱蚊后3次（第1、7、90天）采集血浆样本。采用高灵敏度固相接近结扎法（SP-PLA）测定样品中的sTREM2水平。在43例预后较差的患者中，较高的初始NIH卒中量表（NIHSS）评分（P = 0.005）、早期的sTREM2升高（P < 0.001）和晚期的sTREM2下降（P = 0.002）更为常见。多因素分析显示，NIHSS初始评分（P = 0.015）和sTREM2早期升高（P = 0.032）与预后不良独立相关。本研究结果表明，早期sTREM2水平的增加是预后不良的预测因子。sTREM2的连续随访可能有助于脑卒中后的预后。(C) 2020 Elsevier Ltd.版权所有。
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic stroke (IS) and their association with clinical outcomes were evaluated. A total of 43 patients diagnosed with non-cardioembolic IS between June 2011 and May 2014 were consecutively included in this study. Patients treated with intravenous thrombolysis or intra-arterial thrombectomy were excluded. Plasma samples were collected three times (days 1, 7, and 90) after ictus. The sTREM2 level was measured in the samples using the highly sensitive solid-phase proximity ligation assay (SP-PLA). Among the 43 subjects, higher initial NIH stroke scale (NIHSS) score (P = 0.005), early increment of sTREM2 (P < 0.001), and late decrement of sTREM2 (P = 0.002), were more common in patients with poor outcome. Based on multivariate analysis, initial NIHSS score (P = 0.015) and early increment of sTREM2 (P = 0.032) were independently associated with poor outcome. The results from the present study indicate that increment of sTREM2 level at the early phase was a predictor of poor outcome. Serial follow-up of sTREM2 may aid prognosis after stroke. (C) 2020 Elsevier Ltd. All rights reserved.