The Intrahepatic T Cell Compartment Does Not Normalize Years After Therapy-Induced Hepatitis C Virus Eradication
The Intrahepatic T Cell Compartment Does Not Normalize Years After Therapy-Induced Hepatitis C Virus Eradication
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DOI：
10.1093/infdis/jiv059
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发表时间：
2015-08-01
影响因子：
6.4
通讯作者：
Boonstra, Andre
中科院分区：
文献类型：
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作者：
Spaan, Michelle;Claassen, Mark A. A.;Boonstra, Andre
慢性丙型肝炎病毒（HCV）感染患者在治疗诱导的病毒清除后很长时间内肝脏和血液中的免疫状态知之甚少。在这项研究中，我们证明，清除后4年，调节性T细胞（THEB）和免疫抑制细胞因子白细胞介素10和转化生长因子β对血液中HCV特异性免疫的调节仍在进行中。重要的是，对HCV清除后4年收集的肝脏标本的分析表明，所有患者中仍存在肝内T细胞，表明肝脏T细胞仍受到调节。确定清除后调节HCV特异性记忆T细胞反应的机制与保护性疫苗的开发高度相关，特别是在高风险再感染的患者中。
Little is known about the immune status in liver and blood of patients with chronic hepatitis C virus (HCV) infection long after therapy-induced viral clearance. In this study, we demonstrate that, 4 years after clearance, regulation of HCV-specific immunity in blood by regulatory T cells (Tregs) and the immunosuppressive cytokines interleukin 10 and transforming growth factor beta is still ongoing. Importantly, analysis of liver specimens collected 4 years after HCV clearance shows that intrahepatic Tregs are still present in all patients, suggesting that liver T cells remain regulated. Identifying mechanisms that regulate HCV-specific memory T-cell responses after clearance is highly relevant for the development of protective vaccines, especially in patients at high risk of reinfection.