Does the brain shrink as the waist expands?
Does the brain shrink as the waist expands?
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DOI：
10.1016/j.arr.2014.03.007
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发表时间：
2015-03
影响因子：
13.1
通讯作者：
Kapogiannis D
中科院分区：
文献类型：
--
作者：
Willette AA;Kapogiannis D
最近的研究表明，超重或肥胖与更差的认知能力有关，特别是执行功能。肥胖也可能增加患阿尔茨海默病的风险。因此，人们越来越关注肥胖是否与灰质或白色质（GM，WM）萎缩有关。在这篇综述中，我们确定并严格评估了评估肥胖和GM或WM体积的研究，无论是全球还是特定的感兴趣区域（ROI）。在所有年龄段中，肥胖程度较高始终与额叶GM萎缩相关，特别是在前额皮质。在儿童和< 40岁的成人中，大多数研究发现肥胖与枕叶或顶叶GM体积之间没有关系，而颞叶的结果则是混合的。在中年和老年人中，大多数研究发现，较高的肥胖与顶叶和颞叶GM萎缩有关，而楔前叶、后扣带回和海马的结果则是混合的。在任何年龄组中，高肥胖与全球或区域WM均无明显相关性。我们的结论是，较高的肥胖可能与所有年龄的额叶GM萎缩和顶叶和颞叶GM萎缩在中年和老年。
Recent studies suggest that being overweight or obese is related to worse cognitive performance, particularly executive function. Obesity may also increase the risk of Alzheimer’s disease. Consequently, there has been increasing interest in whether adiposity is related to gray or white matter (GM, WM) atrophy. In this review, we identified and critically evaluated studies assessing obesity and GM or WM volumes either globally or in specific regions of interest (ROIs). Across all ages, higher adiposity was consistently associated with frontal GM atrophy, particularly in prefrontal cortex. In children and adults < 40 years of age, most studies found no relationship between adiposity and occipital or parietal GM volumes, whereas findings for temporal lobe were mixed. In middle-aged and aged adults, a majority of studies found that higher adiposity is associated with parietal and temporal GM atrophy, whereas results for precuneus, posterior cingulate, and hippocampus were mixed. Higher adiposity had no clear association with global or regional WM in any age group. We conclude that higher adiposity may be associated with frontal GM atrophy across all ages and parietal and temporal GM atrophy in middle and old age.