Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
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DOI：
10.1016/s0140-6736(01)07184-7
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发表时间：
2001-12-22
期刊：
影响因子：
168.9
通讯作者：
Laaksonen, R
中科院分区：
文献类型：
--
作者：
Valkonen, VP;Päivä, H;Laaksonen, R
不对称二甲基精氨酸（ADMA）是一种内源性一氧化氮合酶抑制剂，已被认为是内皮功能障碍和冠心病的一个新的独立危险因素。我们研究了血清中ADMA浓度与急性冠状动脉事件风险的关系。我们在芬兰东部的中年男性中进行了一项前瞻性、巢式、病例对照研究。在一项对不吸烟男性的分析中，ADMA水平最高的四分位数（>0.62 μ mol/L）的人与其他四分位数相比，急性冠状动脉事件的风险增加了3.9倍（95%CI 1.25-12.3，p=0.02）。我们的研究结果表明，ADMA是急性冠状动脉事件的预测因子。
Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide synthase Inhibitor, which has been suggested to be a novel independent risk factor for endothelial dysfunction and coronary heart disease. We investigated the association of ADMA concentration In serum with risk of acute coronary events. We did a prospective, nested, case-control study in middle-aged men from eastern Finland. In an analysis of men who did not smoke, those who were in the highest quartile for ADMA (>0.62 mu mol/L) had a 3.9-fold (95% CI 1.25-12.3, p=0.02) increase in risk of acute coronary events compared with the other quartiles. Our findings suggest that ADMA is a predictor of acute coronary events.