Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties
Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties
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DOI：
10.3934/matersci.2017.2.363
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发表时间：
2017-01-01
影响因子：
1.8
通讯作者：
Soman, Pranav
中科院分区：
文献类型：
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作者：
Chen, Yong X.;Cain, Brian;Soman, Pranav
虽然原生细胞外基质（ECM）具有粘弹性，但生物医学工程中用于模拟ECM的合成生物材料在施加外部应变时通常表现出纯弹性响应。为了真正了解活细胞如何与周围的ECM基质相互作用，具有可调粘弹性特性的新型生物材料不断被开发出来。本文报道了明胶甲基丙烯酸盐-海藻酸盐（Gel-Alg）复合水凝胶的合成和力学特性。蠕变和压缩试验结果表明，通过添加或螯合Ca2+离子，凝胶-海藻酸盐组分可以有效地交联、非交联和再交联。这项工作表明，Gel-Alg能够调节其粘弹性应变和弹性恢复特性，并且可以潜在地用于设计模拟ecm的水凝胶。
Although native extracellular matrix (ECM) is viscoelastic, synthetic biomaterials used in biomedical engineering to mimic ECM typically exhibit a purely elastic response when an external strain is applied. In an effort to truly understand how living cells interact with surrounding ECM matrix, new biomaterials with tunable viscoelastic properties continue to be developed. Here we report the synthesis and mechanical characterization of a gelatin methacrylate-alginate (Gel-Alg) composite hydrogel. Results obtained from creep and compressive tests reveal that the alginate component of Gel-Alg composite, can be effectively crosslinked, un-crosslinked and re-crosslinked by adding or chelating Ca2+ ions. This work demonstrates that Gel-Alg is capable of tuning its viscoelastic strain and elastic recovery properties, and can be potentially used to design ECM-mimicking hydrogels.