Doppler echocardiographic prediction of pulmonary hypertension in West Highland white terriers with chronic pulmonary disease.
Doppler echocardiographic prediction of pulmonary hypertension in West Highland white terriers with chronic pulmonary disease.
复制标题
多普勒超声心动图预测患有慢性肺部疾病的西高地白梗的肺动脉高压。
DOI：
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发表时间：
2006
影响因子：
2.6
通讯作者：
H. Baade
中科院分区：
文献类型：
--
作者：
K. Schober;H. Baade
BACKGROUND
Pulmonary hypertension (PH) is commonly diagnosed by Doppler echocardiography (DE) of tricuspid regurgitation (TR). However, TR may be absent or difficult to measure.
HYPOTHESIS
Doppler-derived systolic time intervals of pulmonary artery (PA) flow may be used to predict PH in dogs.
ANIMALS
Seventy-three healthy dogs and 45 West Highland white terriers (WHWT) with interstitial pulmonary disease (IPD).
METHODS
Echocardiographic studies, including determination of right ventricular acceleration time (AT), ejection time (ET), and AT : ET ratio; right ventricular shortening fraction (RV-SF); and TR velocity, were performed. Pulmonary hypertension was defined by TR >3.1 m/s.
RESULTS
In healthy WHWT, AT (median, range) was 73 ms (53 to 104) and AT : ET was 0.40 (0.28 to 0.55). AT : ET was minimally affected by age (R2 = 0.04, 95% confidence interval [CI] 0.01-0.07, P < .001) but not by heart rate, body weight, or RV-SF. In all WHWT with TR, AT and AT : ET were inversely related to calculated systolic PA pressure (R2 = 0.52, 95% CI 0.42-0.62, P < .001 and R2 = 0.36, 95% CI 0.29-0.42, P = .001). Clinical cutoffs to predict systolic PH were defined for AT (58 ms; sensitivity [Se] 88% and specificity [Sp] 80%) and AT : ET (0.31; Se 73% and Sp 87%).
CONCLUSION AND CLINICAL IMPORTANCE
PH is common in WHWT with IPD. Analysis of right ventricular AT and AT : ET may be predictive of PH and should be particularly useful if TR is absent.
影响因子：
37.8
作者：
Nagueh, SF;Kopelen, HA;Zoghbi, WA
通讯作者：
Zoghbi, WA
影响因子：
2.8
作者：
KIRCHER, BJ;HIMELMAN, RB;SCHILLER, NB
通讯作者：
SCHILLER, NB