A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System
A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System
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DOI：
10.1523/jneurosci.2830-16.2016
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发表时间：
2017-01-04
影响因子：
5.3
通讯作者：
Knudsen, Gitte M.
中科院分区：
文献类型：
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作者：
Beliveau, Vincent;Ganz, Melanie;Knudsen, Gitte M.
血清素（5-羟色胺，5-HT）系统调节许多重要的脑功能，并在许多神经精神疾病中发挥重要作用。在这里，我们提出了一个高分辨率，多维，在人体大脑的5-HT受体（5-HT 1A，5-HT 1B，5-HT 2A和5-HT 4）和5-HT转运蛋白（5-HTT）的体内图谱。该图谱是从分子和结构高分辨率神经成像数据创建的，这些数据包括在总共210名健康个体中获得的正电子发射断层扫描（PET）和磁共振成像（MRI）扫描。区域PET结合测量与死后人脑放射自显影结果的比较显示5-HT靶点的高度相关性，这使我们能够将图谱转换为代表蛋白质密度（皮摩尔/毫升）。我们还通过比较图谱中的5-HT密度与来自艾伦人脑图谱的数据，评估了人脑中蛋白质浓度和mRNA表达之间的区域关联，并确定了显示两种测量之间区域关系的受体和转运蛋白特异性关联。总之，这些数据为人类大脑的血清素系统提供了无与伦比的洞察力。
The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT). The atlas is created from molecular and structural high-resolution neuroimaging data consisting of positron emission tomography (PET) and magnetic resonance imaging (MRI) scans acquired in a total of 210 healthy individuals. Comparison of the regional PET binding measures with postmortem human brain autoradiography outcomes showed a high correlation for the five 5-HT targets and this enabled us to transform the atlas to represent protein densities (in picomoles per milliliter). We also assessed the regional association between protein concentration and mRNA expression in the human brain by comparing the 5-HT density across the atlas with data from the Allen Human Brain atlas and identified receptor-and transporter-specific associations that show the regional relation between the two measures. Together, these data provide unparalleled insight into the serotonin system of the human brain.