Association of HLA-DRB1*09:01 with severe COVID-19

Association of HLA-DRB1*09:01 with severe COVID-19
复制标题

DOI：
10.1111/tan.14256
复制
发表时间：
2021-04-13
期刊：
HLA
影响因子：
8
通讯作者：
Kawana-Tachikawa, Ai
Kawana-Tachikawa, Ai
中科院分区：
医学4区
文献类型：
--
作者：
Anzurez, Alitzel;Naka, Izumi;Kawana-Tachikawa, Ai

文献摘要

被引文献

相似文献

分析178例日本COVID-19患者HLA- a、-C、-B和-DRB1基因型，探讨HLA与重症COVID-19的相关性。对4个位点的32个常见HLA等位基因的分析显示，调整年龄、性别和DRB1位点的其他常见HLA等位基因后，HLA-DRB1*09:01与重症COVID-19之间存在显著相关性（优势比[OR] 3.62; 95% CI, 1.57 ~ 8.35; p = 0.00251[排列p值= 0.0418]）。与高血压、糖尿病和心血管疾病等先前存在的疾病相比，DRB1*09:01等位基因与严重COVID-19的风险相关性更大。这些结果表明HLA在严重COVID-19易感性中的潜在作用。
HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*09:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID-19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID-19.