Polycystic ovary syndrome
Polycystic ovary syndrome
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DOI：
10.1016/s0889-8529(05)70286-3
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发表时间：
1997-12-01
影响因子：
4.5
通讯作者：
Dumesic, DA
中科院分区：
文献类型：
--
作者：
Goudas, VT;Dumesic, DA
多囊卵巢综合征(PCOS)的主要临床特征是多毛和无排卵引起的月经不规律。肥胖发生在这些女性中的一半，其中一些人还患有糖尿病。PCOS的潜在生化异常包括黄体生成素(LH)高分泌、高雄激素血症、非周期雌激素产生、性激素结合球蛋白(SHBG)能力下降以及胰岛素抵抗所致的高胰岛素血症，所有这些都导致卵巢雄激素产生增加。在PCOS患者中发现的高胰岛素血症伴随着上半身肥胖，独立于肥胖发生，并通过增加黄体生成素分泌，增强17-羟基酶和17，20-裂解酶的活性，以及抑制SHBG能力来加强卵巢高雄激素生成。所有怀疑有高雄激素性无排卵的女性都应该接受评估，以排除其他内分泌疾病，如男性化肿瘤、成人型先天性肾上腺增生症。
The cardinal clinical features of polycystic ovary syndrome (PCOS) are hirsutism and menstrual irregularity from anovulation. Obesity occurs in one half of these women, some of whom also have diabetes. Underlying biochemical abnormalities in PCOS include luteinizing hormone (LH) hypersecretion, hyperandrogenism, acyclic estrogen production, decreased sex hormone-binding globulin (SHBG) capacity, and hyperinsulinemia from insulin resistance, all of which contribute to increased ovarian androgen production. The hyperinsulinemia found in PCOS women accompanies upper body obesity, occurs independently of obesity alone, and potentiates ovarian hyperandrogenism by enhancing LH secretion, potentiating 17-hydroxylase and, to a lesser extent, 17,20-lyase activity, and suppressing SHBG capacity. All women with suspected hyperandrogenic anovulation should undergo an evaluation to rule out other endocrinopathies, such as virilizing tumors, adult-onset congenital adrenal hyperplasia.