Different Mg to Fe ratios in the mixed metal MgFe hydroxy-carbonate compounds and the effect on phosphate binding compared with established phosphate binders.
Different Mg to Fe ratios in the mixed metal MgFe hydroxy-carbonate compounds and the effect on phosphate binding compared with established phosphate binders.
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DOI：
10.1002/jps.1170
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发表时间：
2002
影响因子：
3.8
通讯作者：
H. Zhu;M. Webb;J. Buckley;N. Roberts
中科院分区：
文献类型：
--
作者：
H. Zhu;M. Webb;J. Buckley;N. Roberts
由于目前口服磷酸盐结合剂的副作用，需要有效的替代品。近年来，许多基于Mg和Fe的混合金属羟基碳酸盐化合物（MMHC）被确定为有效的磷酸盐结合剂。我们现在已经对不同形式的具有不同Mg（2+）：Fe（3+）比例的MMHC进行了进一步的研究，以评估在水溶液和食品浆料中的磷酸盐结合功效和离子释放。提供最有希望的化合物是未老化/干燥形式的Mg（2+）：Fe（3+）比为2：1和4：1的化合物。将它们的磷酸盐结合功效与各种已建立的磷酸盐结合剂进行比较，例如氢氧化铝[Al（OH）（3）]、碳酸钙（CaCO（3））、乙酸钙（CaAc（2））、氢氧化镁[Mg（OH）（2）]和碳酸镧[La（2）（CO（3））（3）]。结果表明，MgFe化合物比已建立的粘合剂有效得多（基于重量），并且它们的性质相对不依赖于pH。钙化合物（CaCO（3）和CaAc（2））在实验条件下无效。Mg（OH）（2）在低pH下有效，但在pH大于5.0时无效，并且释放的镁比MgFe化合物多2 - 3倍。Al（OH）（3）显示出一定程度的功效，但结合能力最多小于MMHC的50%。La（2）（CO（3））（3）需要至少10倍的重量增加才能与MMHC产生相当的结合。总之，MgFe羟基碳酸盐化合物是有效的磷酸盐结合剂，可以提供一个更好的替代现有的和新兴的结合剂，以打击高磷血症。
Due to the side effects of the current oral phosphate binders, there is a need for effective alternatives. A number of mixed metal hydroxy-carbonate compounds (MMHCs) based on Mg and Fe have recently been established as effective phosphate binders. We have now carried out further studies on the MMHCs with different ratios of Mg(2+):Fe(3+) in different forms to assess for phosphate binding efficacy and ionic release in aqueous solution and food slurries. The compounds that provide the most promise are those with Mg(2+):Fe(3+) ratios of 2:1 and 4:1 in the unaged/dry form. Their phosphate binding efficacy was compared with a wide range of established phosphate binders, such as aluminum hydroxide [Al(OH)(3)], calcium carbonate (CaCO(3)), calcium acetate (CaAc(2)), magnesium hydroxide [Mg(OH)(2)], and lanthanum carbonate [La(2)(CO(3))(3)] in various food slurries. The results showed that the MgFe compounds were much more effective (on a weight for weight basis) than the established binders, and their properties were relatively pH independent. Calcium compounds (CaCO(3) and CaAc(2)) were ineffective under the experimental conditions. Mg(OH)(2) was effective at low pH but not at pHs greater than 5.0, and also released two- to threefold more magnesium than the MgFe compounds. Al(OH)(3) showed some degree of efficacy, but the binding capacity was, at best, less than 50% of the MMHCs. La(2)(CO(3))(3) required at least a 10-fold increase in weight to give comparable binding to the MMHCs. In conclusion, MgFe hydroxy-carbonate compounds are effective phosphate binders and may provide a better alternative to both existing and emerging binders for combating hyperphosphataemia.