MELATONIN EXCRETION, BODY-TEMPERATURE AND SUBJECTIVE AROUSAL DURING 64 HOURS OF SLEEP-DEPRIVATION
MELATONIN EXCRETION, BODY-TEMPERATURE AND SUBJECTIVE AROUSAL DURING 64 HOURS OF SLEEP-DEPRIVATION
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DOI：
10.1016/0306-4530(79)90005-2
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发表时间：
1979-01-01
影响因子：
3.7
通讯作者：
WETTERBERG, L
中科院分区：
文献类型：
--
作者：
AKERSTEDT, T;FROBERG, JE;WETTERBERG, L
通过对 12 名健康男性进行放射免疫测定来测量褪黑激素，有证据表明，当受试者暴露在光线下时，睡眠不足时，褪黑激素的尿液排泄遵循昼夜节律模式。褪黑激素的排泄随着睡眠不足的增加而增加。恢复睡眠期间褪黑激素的分泌与基线睡眠期间没有差异。褪黑激素的排泄不会在低谷时期对心理社会压力做出反应（如肾上腺素[肾上腺素]那样）。自评疲劳和体温表现出昼夜节律变化。疲劳峰值和体温谷值在时间上与褪黑激素排泄峰值一致。
Evidence was presented, based on measurement of melatonin by radioimmunoassay in 12 healthy males, that the urinary excretion of melatonin follows a circadian pattern in humans during sleep deprivation when the subjects are exposed to light. Melatonin excretion increased with increased sleep deprivation. Melatonin excretion during recovery sleep did not differ from that during base line sleep. Melatonin excretion did not react to psychosocial stress at trough times (as adrenaline [epinephrine] did). Self-rated fatigue and body temperature exhibited a circadian variation. Peak fatigue and trough body temperature coincided temporally with the peak of melatonin excretion.