Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage.
Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage.
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DOI：
10.1007/s12026-008-8081-6
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发表时间：
2009
影响因子：
4.4
通讯作者：
Margulies, David H.
中科院分区：
文献类型：
--
作者：
Mans, Janet;Zhi, Li;Revilleza, Maria Jamela R.;Smith, Lee;Redwood, Alec;Natarajan, Kannan;Margulies, David H.
关键词：
The mouse cytomegalovirus (CMV), a β-herpesvirus, exploits its large (~230 kb) double-stranded DNA genome for both essential and non-essential functions. Among the non-essential functions are those that offer the virus selective advantage in eluding both the innate and adaptive immune responses of the host. Several non-essential genes of MCMV are thought to encode MHC-I-like genes and to function as immunoevasins. To understand further the evolution and function of these viral MHC-I (MHC-Iv) molecules, X-ray structures of several of them have been determined, confirming the overall MHC-I-like structure, but also elucidating features unique to this family. Future efforts promise to clarify the nature of the molecular ligands of these molecules, their evolution in the context of the adapting immune response of the murine host, and by analogy the evolution of the host response to human CMV as well.
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1084/jem.20021973
发表时间：
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期刊：
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DOI：
10.1084/jem.20060514
发表时间：
2006-08-07
期刊：
The Journal of experimental medicine
影响因子：
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影响因子：
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作者：
Holtappels, Rafaela;Gillert-Marien, Dorothea;Reddehase, Matthias J.
通讯作者：
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