Spatial learning and memory at defined points of the estrous cycle: Effects on performance of a hippocampal-dependent task
Spatial learning and memory at defined points of the estrous cycle: Effects on performance of a hippocampal-dependent task
复制标题
DOI：
10.1037/0735-7044.111.2.267
复制
发表时间：
1997-04-01
影响因子：
1.9
通讯作者：
Gallagher, M
中科院分区：
文献类型：
--
作者：
Berry, B;McMahan, R;Gallagher, M
在与低（发情）和高（发情前）循环雌激素相对应的发情周期的确定点，评估雌性大鼠基于海马依赖空间导航的学习能力。通过水迷宫程序的背景训练，大鼠在一次8次训练试验中学会了迷宫中逃生平台的位置。在一项用于评估训练后30分钟学习记忆的探针试验中，对逃生平台的强烈空间偏差也很明显。整个程序不到一个小时就完成了。发情大鼠和前发情大鼠的表现在所有行为测量中都没有区别，而与任务期间的发情周期阶段无关。这些结果表明，尽管正常循环的雌性大鼠海马树突棘密度发生了形态学改变，但在相对短的时间内保持了空间信息的快速学习和保留。
Learning based on hippocampal-dependent spatial navigation in female rats was assessed at identified points in the estrous cycle corresponding to low (estrus) and high (proestrus) circulating estrogen. With background training in water-maze procedures, rats learned the location of an escape platform in the maze in a single session of 8 training trials. A strong spatial bias for the escape platform was also evident in a probe trial used to assess retention of learning 30 min after the training session. This entire protocol was completed in less than an hour. The performance of the estrus and proestrus rats was indistinguishable on all behavioral measures, irrespective of the stage of estrous cycle during the task. These results indicate that rapid learning and retention for spatial information over a relatively short interval may be preserved despite morphological alterations in hippocampal dendritic spine density in the normally cycling female rat.