The influence of transforming growth factor-α, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer
The influence of transforming growth factor-α, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer
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DOI：
10.1111/j.1365-2559.2011.04139.x
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发表时间：
2012-08-01
期刊：
影响因子：
6.4
通讯作者：
Montagnini, Andre Luis
中科院分区：
文献类型：
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作者：
Fanelli, Marcello Ferretti;Chinen, Ludmilla T. Domingos;Montagnini, Andre Luis
Fanelli M F，Chinen L T D，Begnami M D，Costa W L Jr，Fregnami J H T，Soares F A & Montagnini A L？（2012）Histopology similar to 61，153161转化生长因子-α、环氧合酶-2、基质金属蛋白酶（MMP）-7、MMP-9和CXCR 4蛋白参与上皮间质转化对胃癌患者总体存活的影响确定预测胃癌（GC）生存的预后参数可以更好地识别可以从当前化疗方案中获益的患者。为了评估肿瘤进展与上皮间质转化（EMT）之间的相关性，我们测定了参与EMT的选定分子[CD 44、转化生长因子（TGF）-α、环氧合酶-2（考克斯-2）、基质金属蛋白酶（MMP）-7、MMP-9和C-X-C趋化因子受体（CXCR 4）]的表达水平，并将这些与患者的总生存期（OS）和疾病分期相关联。方法和结果：对137例胃癌患者的病历和病理活检结果进行回顾性分析。Spearmans相关分析显示CXCR 4的表达与所有其他蛋白的表达显著相关。相反，考克斯-2的表达仅与MMP-7（P = 0.011）、MMP-9（P = 0.015）和CXCR 4（P = 0.013）的表达显著相关。TGF-α（P = 0.017）、考克斯-2（P < 0.001）、CXCR 4（P = 0.010）、MMP-7（P = 0.020）和MMP-9（P = 0.015）的表达与总生存期呈显著负相关。多因素分析显示，只有考克斯-2是影响OS的独立预后因素[风险比（HR）= 3.34; 95%可信区间（CI）：1.439.75; P = 0.002]。结论：考克斯-2、TGF-α、MMP-7、MMP-9和CXCR 4与胃癌的低OS相关。
Fanelli M F, Chinen L T D, Begnami M D, Costa W L Jr, Fregnami J H T, Soares F A & Montagnini A L ?(2012) Histopathology similar to 61, 153161 The influence of transforming growth factor-a, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelialmesenchymal transition on overall survival of patients with gastric cancer Aims: Determination of prognostic parameters that are predictive of survival of gastric cancer (GC) may allow better identification of patients who could benefit from current chemotherapy regimens. To assess the correlation between tumour progression and epithelialmesenchymal transition (EMT), we assayed the expression levels of selected molecules involved in EMT [CD44, transforming growth factor (TGF)-a, cyclooxygenase-2 (COX-2), matrix metalloproteinase (MMP)-7, MMP-9 and C-X-C chemokine receptor (CXCR4)], and correlated these with overall patient survival (OS) and disease stage. Methods and results: Medical records and pathological biopsy results of 137 patients with GC were evaluated retrospectively. Spearmans correlation analysis showed that expression of CXCR4 was correlated significantly with the expression of all other proteins studied. In contrast, COX-2 expression correlated significantly with the expression of only MMP-7 (P = 0.011), MMP-9 (P = 0.015) and CXCR4 (P = 0.013). We observed significant negative correlations between OS and the expression of TGF-a (P = 0.017), COX-2 (P < 0.001), CXCR4 (P = 0.010), MMP-7 (P = 0.020) and MMP-9 (P = 0.015). On multivariate analysis, only COX-2 was an independent prognostic factor for OS [hazard ratio (HR) = 3.34; 95% confidence interval (CI): 1.439.75; P = 0.002). Conclusions: COX-2, TGF-a, MMP-7, MMP-9 and CXCR4 are associated with poor OS in gastric cancer.